... and metabolic homeostasis. Inappropriate Wnt pathway activation results in diseases, including colorectal cancer. The adenomatous polyposis coli ( APC ) tumor suppressor gene encodes a multifunctional protein that is an essential regulator of Wnt signaling and cytoskeletal organization. Although progress has...

...(UAS:Kaede) rk8Tg ( Hatta et al., 2006 ), Tg(fli1a:Gal4FF) ubs4 ( Zygmunt et al., 2011 ), Tg(UAS:Brainbow) s1997t ( Robles et al., 2013 ), Tg(UAS:GFP) nkuasgfp1a ( Asakawa et al., 2008 ), Tg(TP1:VenusPEST) s940 ( Ninov et al., 2012 ), apc hu745/+ ( Hurlstone et al., 2003 ), Tg(fli1:Gal4db...

... suppressor adenomatous polyposis coli ( APC ) initiate most colon cancers and have also been suggested to promote disease progression through increased CIN, but the mechanistic role of APC in preventing CIN remains controversial. Using fly embryos as a model, we investigated the role of APC proteins in CIN...

...Julia B. Cordero; Rhoda K. Stefanatos; Kevin Myant; Marcos Vidal; Owen J. Sansom Inactivating mutations within adenomatous polyposis coli ( APC ), a negative regulator of Wnt signaling, are responsible for most sporadic and hereditary forms of colorectal cancer (CRC). Here, we use the adult...

... a threshold for the amount of this form of Armadillo and therefore for Wnt signalling. In the current model of Wnt signalling, a complex assembled around Axin and Apc allows GSK3 (Shaggy) to phosphorylate Armadillo and target it for degradation. However, genetic experiments suggest that the loss of function...

... by a population of multipotent intestinal stem cells (ISCs) that resides in epithelial niches. Adenomatous polyposis coli ( Apc ), a tumor suppressor gene conserved in both invertebrates and vertebrates, is known to play a role in multiple developmental processes in Drosophila . Here, we examine the consequences...

...Xiu-Ping Wang; Daniel J. O'Connell; Jennifer J. Lund; Irfan Saadi; Mari Kuraguchi; Annick Turbe-Doan; Resy Cavallesco; Hyunsoo Kim; Peter J. Park; Hidemitsu Harada; Raju Kucherlapati; Richard L. Maas The ablation of Apc function or the constitutive activation ofβ-catenin in embryonic mouse oral...

... and homeostasis are affected following inactivation of an endogenous inhibitor of β-catenin,adenomatous polyposis coli (Apc). In adult mice, Apc-deficient pancreata were enlarged, solely as a result of hyperplasia of acinar cells, which accumulatedβ-catenin, with the sparing of islets. Expression of a target ofβ...

...Andrew Swan; Trudi Schüpbach Meiosis is a highly specialized cell division that requires significant reorganization of the canonical cell-cycle machinery and the use of meiosis-specific cell-cycle regulators. The anaphase-promoting complex (APC)and a conserved APC adaptor, Cdc20 (also known as Fzy...

...Pauline Andreu; Sabine Colnot; Cécile Godard; Sophie Gad; Philippe Chafey; Michiko Niwa-Kawakita; Pierre Laurent-Puig; Axel Kahn; Sylvie Robine; Christine Perret; Béatrice Romagnolo Loss of Apc appears to be one of the major events initiating colorectal cancer. However, the first events...

... ) 30 4 2004 © 2004. 2004 Meiotic cell cycle AP polarity E3 ligase C. elegans APC The meiotic cell cycle differs from the mitotic cell cycle in several respects. One key difference lies in the fact that the two meiotic divisions occur without an intervening S phase, thus...

...Yashi Ahmed; Ali Nouri; Eric Wieschaus Inactivation of the Adenomatous Polyposis Coli (APC) tumor suppressor triggers the development of most colorectal carcinomas. APC is required for targeted degradation of β-catenin, the central transcriptional activator in the Wnt/Wingless (Wg) signal...