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Keywords: Apc
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Journal Articles
Journal Articles
Journal: Development
Development (2016) 143 (12): 2217–2227.
Published: 15 June 2016
... of a complete EMT. The requirement of Wnt/β-catenin signaling for endocardial cell migration towards the abluminal side of the immature valve is also supported by our observation that an increased number of endocardial cells appear to exhibit a cone-shaped nucleus in apc mutants. These cone-shaped nuclei...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4226–4236.
Published: 15 October 2013
... suppressor adenomatous polyposis coli ( APC ) initiate most colon cancers and have also been suggested to promote disease progression through increased CIN, but the mechanistic role of APC in preventing CIN remains controversial. Using fly embryos as a model, we investigated the role of APC proteins in CIN...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2011) 138 (8): 1501–1506.
Published: 15 April 2011
... a threshold for the amount of this form of Armadillo and therefore for Wnt signalling. In the current model of Wnt signalling, a complex assembled around Axin and Apc allows GSK3 (Shaggy) to phosphorylate Armadillo and target it for degradation. However, genetic experiments suggest that the loss of function...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (13): 2255–2264.
Published: 1 July 2009
... by a population of multipotent intestinal stem cells (ISCs) that resides in epithelial niches. Adenomatous polyposis coli ( Apc ), a tumor suppressor gene conserved in both invertebrates and vertebrates, is known to play a role in multiple developmental processes in Drosophila . Here, we examine the consequences...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2007) 134 (15): 2719–2725.
Published: 1 August 2007
... and homeostasis are affected following inactivation of an endogenous inhibitor of β-catenin,adenomatous polyposis coli (Apc). In adult mice, Apc-deficient pancreata were enlarged, solely as a result of hyperplasia of acinar cells, which accumulatedβ-catenin, with the sparing of islets. Expression of a target ofβ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (5): 891–899.
Published: 1 March 2007
...Andrew Swan; Trudi Schüpbach Meiosis is a highly specialized cell division that requires significant reorganization of the canonical cell-cycle machinery and the use of meiosis-specific cell-cycle regulators. The anaphase-promoting complex (APC)and a conserved APC adaptor, Cdc20 (also known as Fzy...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2004) 131 (15): 3527–3543.
Published: 1 August 2004
... contributed centrosomes. Relevant to this view are experiments conducted with conditional mutants in APC components. At the restrictive temperature, such mutants arrest at the metaphase to anaphase transition of meiosis I( Golden et al., 2000 ; Wallenfang and Seydoux, 2000 ). Approximately 40...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (7): 1751–1762.
Published: 1 April 2002
...Yashi Ahmed; Ali Nouri; Eric Wieschaus Inactivation of the Adenomatous Polyposis Coli (APC) tumor suppressor triggers the development of most colorectal carcinomas. APC is required for targeted degradation of β-catenin, the central transcriptional activator in the Wnt/Wingless (Wg) signal...