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Keywords: Antisense regulation
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Journal Articles

Crucial role of antisense transcription across the Xist promoter in Tsix -mediated Xist chromatin modification

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Tatsuya Ohhata, Yuko Hoki, Hiroyuki Sasaki, Takashi Sado
Journal: Development
Development (2008) 135 (2): 227–235.
https://doi.org/10.1242/dev.008490
Published: 15 January 2008
... found that although 93% of the region encoding Tsix was transcribed, truncation of Tsix abolished the antisense regulation of Xist . This resulted in a failure to establish the repressive chromatin configuration at the Xist promoter on the mutated X, including DNA methylation and repressive histone...
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Includes: Supplementary data
Journal Articles

Tsix defective in splicing is competent to establish Xist silencing

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Takashi Sado, Yuko Hoki, Hiroyuki Sasaki
Journal: Development
Development (2006) 133 (24): 4925–4931.
https://doi.org/10.1242/dev.02670
Published: 15 December 2006
... was properly established at the Xist locus. These unexpected results indicate that the splicing products are dispensable for Tsix -mediated Xist silencing. * Author for correspondence (e-mail: [email protected] ) 3 10 2006 © 2006. 2006 X-inactivation Antisense regulation Xist...
View articletitled, Tsix defective in splicing is competent to establish Xist silencing
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