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Keywords: Antisense
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Journal Articles
Journal: Development
Development (2006) 133 (1): 15–20.
Published: 1 January 2006
... embryos: an antisense approach. In A Comparative Methods Approach to the Study of Oocytes and Embryos (ed. J. D. Richter), pp. 341 -354. Oxford: Oxford University Press. Many thanks to Dr Dan Kessler for supplying the Vg1 antibody and the Vg1(P)plasmid, and for much advice; to Aaron Zorn and Scott...
Journal Articles
Journal: Development
Development (2005) 132 (14): 3267–3279.
Published: 15 July 2005
... and negative functions, dictates cell fate and behavior. Using an antisense approach to knockdown gene function in vivo, we find that each of the three Gli proteins is required for the induction of all primary neurons in the amphibian neural plate and regulates the bHLH/Notch neurogenic cascade. Analyses...
Journal Articles
Journal: Development
Development (2005) 132 (5): 1105–1116.
Published: 1 March 2005
... alleles all contain transversions in highly conserved amino acids of the extracellular domains,suggesting these alleles produce dominant-negative effects. Antisense oligonucleotides that create specific splicing defects in the hab mRNA phenocopy the recessive phenotypes and, surprisingly, some of the ZMD...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (20): 5065–5078.
Published: 15 October 2004
... expression in the early embryo. * Author for correspondence (e-mail: heabq9@chmcc.org ) 5 8 2004 © 2004. 2004 Foxh1 Fast1 Antisense Nodal Xnr5 Xnr6 Xnr3 Xenopus FoxH1 (Fast1) was first characterized as the transcriptional partner for Smad proteins forming...
Journal Articles
Journal: Development
Development (1998) 125 (23): 4791–4801.
Published: 1 December 1998
...) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and cardiotrophin-1 (CT-1). To interfere with the function of these neuropoietic cytokines in vivo, antisense RNA for gp130, the common signal-transducing receptor subunit for neuropoietic...
Journal Articles
Journal: Development
Development (1996) 122 (8): 2539–2554.
Published: 1 August 1996
... and X). In vivo expression of an α6 antisense transcript in the animal hemisphere leads to a reduction in α6 protein expression, a loss of adhesion to laminin, and severe defects in normal development. In 35% of cases, reduced levels of α6 expression result in embryos that complete gastrulation normally...
Journal Articles
Journal: Development
Development (1993) 119 (3): 711–720.
Published: 1 November 1993
..., we have generated a loss-of-function phenotype using antisense oligonucleotides in mouse kidney organ cultures. These oligonucleotides can specifically inhibit Pax-2 protein accumulation in kidney mesenchyme cells, where the intracellular concentrations are maximal. The kidney organ cultures were...
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (1991) 111 (4): 1173–1178.
Published: 1 April 1991
...D. L. Weeks; J. A. Walder; John M. Dagle ABSTRACT The control of the cell cycle is dependent on the ability to synthesize and degrade proteins called cyclins. When antisense oligonucleotides are used to deplete Xenopus embryos of mRNA encoding cyclin B protein, embryonic cleavage is inhibited...