...Megan J. Wilson; Peter K. Dearden Axis formation is a key step in development, but studies indicate that genes involved in insect axis formation are relatively fast evolving. Orthodenticle genes have conserved roles, often with hunchback , in maternal anterior patterning in several insect species...

... requirement for early anterior patterning and proper gastrulation but it failed to maintain forebrain and midbrain identity. Importantly, epiblast and neuroectoderm translation of otd 2FL mRNA rescued maintenance of anterior patterning as it did in a third mouse model replacing, as in otd 2FL , exons...

... by the combination of AVE, EPI and EGO therefore emulates, in an experimental setting, the normal outcome of the interactions of these tissues during anterior patterning. The EGO of the mouse may possess both the head and trunk organizing activity. The head organizing activity, however, is ineffective in the absence...