... downregulation of Pax6 with either the NURF nucleosome remodeling complex or the Pointed transcription factor transforms the head epidermis into an antenna. This is a previously unidentified fate change that is also not observed with the loss of individual genes. We propose that the use of multi-gene knockdowns...

... ). Transformation of the eye to antenna by misexpression of a single gene . Mech. Dev. 125 , 130 – 141 . Dobzhansky T. ( 1930 ). Time of development of the different sexual forms in Drosophila melanogaster . Biol. Bull. 59 , 128 – 133 . Ferris G. F. ( 1950 ). External morphoogy...

... as potential targets of Dll activation specifically in the developing antenna. These are spalt ( sal ) ( Dong et al., 2000 ), dachshund ( dac ) ( Dong et al., 2001 ) and atonal ( ato ) ( Dong et al., 2002 ). Intriguingly, all three of these genes have vertebrate homologs that are expressed in either...

...P. D. Si Dong; Jennifer Scholz Dicks; Grace Panganiban The Drosophila antenna is a highly derived appendage required for a variety of sensory functions including olfaction and audition. To investigate how this complex structure is patterned, we examine the specific functions of genes required...

...Jessie Chu; P. D. Si Dong; Grace Panganiban The insect antenna and leg are considered homologous structures, likely to have arisen via duplication and divergence from an ancestral limb. Consistent with this, the antenna and leg are derived from primordia with similar developmental potentials...

...P. D. Si Dong; Jessie Chu; Grace Panganiban The morphological diversification of appendages represents a crucial aspect of animal body plan evolution. The arthropod antenna and leg are homologous appendages, thought to have arisen via duplication and divergence of an ancestral structure (Snodgrass...

...P. D. Si Dong; Jessie Chu; Grace Panganiban ABSTRACT The Distal-less gene is known for its role in proximodistal patterning of Drosophila limbs. However, Distal-less has a second critical function during Drosophila limb development, that of distinguishing the antenna from the leg. The antenna...