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Keywords: Angiogenesis
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Journal Articles
Journal: Development
Development (2021) 148 (15): dev197509.
Published: 12 August 2021
... mutants in zebrafish embryos reveals distinct functions of Rasip1 during sprouting angiogenesis, anastomosis and lumen formation. During angiogenic sprouting, loss of Rasip1 causes cell pairing defects due to a destabilization of tricellular junctions, indicating that stable tricellular junctions...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (9): dev182279.
Published: 01 May 2020
... angiogenesis and neurovascular barrier maturation have been elucidated in recent years. Yet how neuronal activity influences these processes remains largely unexplored. Here, we discuss our current understanding of how neuronal and glial development affects CNS angiogenesis and barriergenesis, and outline...
Journal Articles
Journal: Development
Development (2020) 147 (7): dev185405.
Published: 06 April 2020
...Lilian Schimmel; Daisuke Fukuhara; Mark Richards; Yi Jin; Patricia Essebier; Emmanuelle Frampton; Marie Hedlund; Elisabetta Dejana; Lena Claesson-Welsh; Emma Gordon ABSTRACT Endothelial cell adhesion is implicated in blood vessel sprout formation, yet how adhesion controls angiogenesis, and whether...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (16): dev181024.
Published: 27 August 2019
... angiogenesis . Development   134 , 839 - 844 . 10.1242/dev.003244 Lucitti , J. L. , Jones , E. A. , Huang , C. , Chen , J. , Fraser , S. E. and Dickinson , M. E. ( 2007 ). Vascular remodeling of the mouse yolk sac requires hemodynamic force . Development   134 , 3317...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev175117.
Published: 17 April 2019
... of the retinal astrocyte population and the resulting supra-physiological astrocyte abundance prevented retinal vascular pruning in neonatal mice. Vascular pruning Angiogenesis Retinal astrocytes Hypoxia PHD2 Retinal vascular development is spatially and temporally coordinated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev161182.
Published: 02 July 2018
... are unable to re-distribute within the vascular network. Vascular malformations Cdc42 Cell migration Endothelial axial polarity Angiogenesis Proliferation The small GTPase cell division cycle 42 (Cdc42) is present in most eukaryotes, where it exerts basic functions in the regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev157511.
Published: 25 April 2018
... disease. In development, the influence of neuroprogenitor cells on angiogenesis is poorly understood. Here, we show in mouse that these cells interact intimately with the growing retinal vascular network, and we identify a novel regulatory mechanism of vasculature development mediated by hypoxia-inducible...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (13): 2428–2444.
Published: 01 July 2017
.... Wilson; Joshua D. Wythe The transcriptional pathways activated downstream of vascular endothelial growth factor (VEGF) signaling during angiogenesis remain incompletely characterized. By assessing the signals responsible for induction of the Notch ligand delta-like 4 (DLL4) in endothelial cells, we find...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (13): 2392–2401.
Published: 01 July 2017
... Industries. References Adams , R. H. and Alitalo , K. ( 2007 ). Molecular regulation of angiogenesis and lymphangiogenesis . Nat. Rev. Mol. Cell. Biol.   8 , 464 - 478 . 10.1038/nrm2183 Adams , R. H. and Eichmann , A. ( 2010 ). Axon guidance molecules in vascular...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (8): 1554–1565.
Published: 15 April 2017
...Loïc Sauteur; Markus Affolter; Heinz-Georg Belting The cardiovascular system forms during early embryogenesis and adapts to embryonic growth by sprouting angiogenesis and vascular remodeling. These processes require fine-tuning of cell-cell adhesion to maintain and re-establish endothelial contacts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (5): 889–896.
Published: 01 March 2017
...Jessica E. Nesmith; John C. Chappell; Julia G. Cluceru; Victoria L. Bautch Blood vessel formation is essential for vertebrate development and is primarily achieved by angiogenesis – endothelial cell sprouting from pre-existing vessels. Vessel networks expand when sprouts form new connections...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3796–3805.
Published: 15 October 2016
...) preferentially occurs in endothelial cells undergoing angiogenesis, but not in committed arterial endothelial cells. pERK in endothelial cells was ectopically induced by Vegfa and lost in Vegfa signaling mutants. Both chemical and endothelial autonomous inhibition of ERK prevented endothelial sprouting, but did...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3582–3590.
Published: 01 October 2016
... and embryonic lethality at mid-gestation. During perinatal retinal angiogenesis, inhibition of PKA resulted in hypersprouting as a result of increased numbers of tip cells. In zebrafish, cell autonomous PKA inhibition also increased and sustained endothelial cell motility, driving cells to become tip cells...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3037–3044.
Published: 01 September 2016
... and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, our mechanistic understanding of Slit-Robo signaling has progressed enormously. Here, we summarize new insights into Slit-Robo evolutionary and system-dependent diversity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (16): 2973–2982.
Published: 15 August 2016
...Emma C. Watson; Monica N. Koenig; Zoe L. Grant; Lachlan Whitehead; Evelyn Trounson; Grant Dewson; Leigh Coultas The growth of hierarchical blood vessel networks occurs by angiogenesis. During this process, new vessel growth is accompanied by the removal of redundant vessel segments by selective...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2706–2715.
Published: 01 August 2016
... developmental and regenerative bone formation and providing niche microenvironments for various cell types. Bone Angiogenesis Blood vessels Endothelial cell Chondrocyte Osteoblast Osteoclast The skeletal system – a framework of bones and connective tissues – provides essential structural...
Journal Articles
Journal: Development
Development (2016) 143 (14): 2593–2602.
Published: 15 July 2016
... lumenized arteries. Angiogenesis Arteriovenous malformation Alk1/Acvrl1 Endocardium Hereditary hemorrhagic telangiectasia Zebrafish Hereditary hemorrhagic telangiectasia (HHT) is characterized by a predisposition to development of arteriovenous malformations (AVMs). These fragile, direct...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (13): 2249–2260.
Published: 01 July 2016
... to these networks at a single-cell level in vivo . This Review summarizes what is known about endothelial cell behavior during developmental angiogenesis, focusing on the morphogenetic changes that these cells undergo. During the past decade, much progress has been made in understanding how the behavior...
Journal Articles
Journal: Development
Development (2016) 143 (4): 589–594.
Published: 15 February 2016
...Alexandra M. Ochsenbein; Sinem Karaman; Steven T. Proulx; Michaela Berchtold; Giorgia Jurisic; Esther T. Stoeckli; Michael Detmar Vascular endothelial growth factor (VEGF)-A is a well-known major chemoattractant driver of angiogenesis – the formation of new blood vessels from pre-existing ones...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (2): 348–355.
Published: 15 January 2016
... results in a delay in vascular invasion and growth plate maturation due to increased ubiquitin-dependent degradation of VEGF. c-Raf Growth plate Chondrocyte apoptosis VEGF Angiogenesis Mouse During endochondral bone formation, mesenchymal cells condense to differentiate...
Includes: Supplementary data