...Adam W. Olson; Vien Le; Jinhui Wang; Alex Hiroto; Won Kyung Kim; Dong-Hoon Lee; Joseph Aldahl; Xiwei Wu; Minhyung Kim; Gerald R. Cunha; Sungyong You; Zijie Sun ABSTRACT Stromal androgen-receptor (AR) action is essential for prostate development, morphogenesis and regeneration. However, mechanisms...

... position relative to the smooth muscle layer. In vitro recombination experiments demonstrated that direct contact with the VMP led to the induction of very few epithelial buds, and that androgens dramatically increased bud development. Taken together, our data suggest that differentiation of a smooth...

...Axel A. Thomson; Barbara A. Foster; Gerald R. Cunha ABSTRACT Development of the mammalian male accessory sexual organs requires both androgens and mesenchymal/epithelial interactions. Paracrine acting factors whose expression is mesenchymal and androgen dependent have been proposed to regulate...

... or neonatal bladder or urethral epithelium. These tissue recombinants made dorsolateral but not ventral prostatic secretory proteins. None of them developed into seminal vesicle. To examine whether epithelial androgen receptors were required for this process, seminal vesicle mesenchyme was recombined...

...Ryutaro Murakami; Takeo Mizuno SUMMARY The penis of adult rats comprises the corpus cavernosum penis and the proximal and distal segments of os penis which are situated proximal–distally in this order. Androgens are necessary for the phenotypic differentiation of these tissues. In the present study...