..., regulation and function of the jagged 2 ( Jag2 ) gene, which encodes a ligand for the Notch family of receptors, in developing mouse teeth. Jag2 is expressed in epithelial cells that give rise to the enamel-producing ameloblasts from the earliest stages of tooth development. Tissue recombination experiments...

... genes function to ensure that enamel-producing ameloblasts are generated on only one side of the tooth by inhibiting the formation of ectopic ameloblasts from self-renewing stem cells, and that they do so by preventing the establishment of an epithelial-mesenchymal FGF signaling loop. Interestingly...

... showing the absence of ISL1 in functional ameloblasts of a P1 molar. (D) High magnification demonstrating nuclear ISL1 staining in ameloblasts of the enamel-free cusp region of a P4 molar. a, ameloblasts; ab, alveolar bone; d,dentin; df, dental follicle; e, enamel; eo, enamel organ; o, odontoblasts; oe...