...Alexandra Krol; Steven J. Henle; Lisa V. Goodrich Neurons exhibit asymmetric morphologies throughout development – from migration to the elaboration of axons and dendrites – that are correctly oriented for the flow of information. For instance, retinal amacrine cells migrate towards the inner...

... ). In the vertebrate retina, the six major neuronal cell types and one type of Müller glia are arranged in a well-defined laminar structure. Whereas photoreceptors (rod and cones) are located in the outer nuclear layer (ONL),the three types of interneurons (bipolar, horizontal and amacrine cells) and the Müller...

... leads to a fate-switch in these precursors that causes them to adopt a ganglion cell fate. This mis-specification of neurons results in a complete loss of horizontal cells, a profound decrease of amacrine cells and an increase in ganglion cells. Furthermore, we identify Ptf1a as a primary downstream...

...Tomoyuki Inoue; Masato Hojo; Yasumasa Bessho; Yasuo Tano; Jacqueline E. Lee; Ryoichiro Kageyama The basic helix-loop-helix genes Math3 and NeuroD are expressed by differentiating amacrine cells, retinal interneurons. Previous studies have demonstrated that a normal number of amacrine cells...

... later confined to the external inner nuclear layer. We show that these horizontal cells co-express TrkA and NGF, unlike a subpopulation of amacrine cells that only expresses TrkA. In contrast to the horizontal cells, which survive, the majority of the TrkA-expressing amacrine cells die during a period...

... the distribution nor the proportion of the major retinal cell types (rod and cone photoreceptors, bipolar cells, amacrine cells, horizontal cells, Müller glia) was affected in the mutant animals (representative sections are shown in Fig. 5A-H and cell counts are summarized in Fig. 5I ). Several...

... and horizontal cells, but no cone photoreceptors. During this same period, a comparable number of cone photoreceptors were generated by VC1.1 - progenitors. In the late embryonic and early postnatal period, VC1.1 + progenitors continued to generate predominantly amacrine cells, but also gave rise...