... that the retromer complex is involved in specific developmental processes. Moreover, a number of recent studies implicate aberrant retromer function in photoreceptor degeneration, Alzheimer's disease and Parkinson's disease. Here, and in the accompanying poster, we provide an overview of the molecular and cellular...

...Bernard Lakowski; Stefan Eimer; Christine Göbel; Andreas Böttcher; Babett Wagler; Ralf Baumeister Mutations in presenilin genes are associated with familial Alzheimer's disease in humans and affect LIN-12/Notch signaling in all organisms tested so far. Loss of sel-12 presenilin activity...

...Melissa Handler; Xudong Yang; Jie Shent ABSTRACT Mutations in Presenilin-1 (PSP) are a major cause of familial Alzheimer’s disease. Our previous studies showed that PS1 is required for murine neural development. Here we report that lack of PS1 leads to premature differentiation of neural progenitor...

...Diane Levitan; Iva Greenwald ABSTRACT Presenilins have been implicated in the development of Alzheimer’s disease and in facilitating LIN-12/Notch activity. Here, we use genetic methods to explore the relationship between C. elegans LIN-12 and SEL-12 presenilin. Reducing sel-12 activity can suppress...