... , red arrowhead). Bmp had no effect on Pitx2 ( Fig. 5A,G,M,Mi , blue arrowheads) or Twist expression ( Fig. 5E,K,Q,Qi , blue arrowheads). However, exposure to Bmp advanced the onset of Alx4 expression to late phase 1 ( Fig. 5H , green arrowhead) and induced ectopic expression of Alx4 in phase 2...

... of the majority of the autopod skeletal elements. We show that FGFR1 deficiency does not affect cell proliferation. Instead, it triggers cell death and leads to alterations in expression of a number of genes involved in apoptosis and digit patterning, including increased expression of Bmp4 , Dkk1 and Alx4...

..., however, through a regulative pathway of skeletogenesis that is responsive to cell signaling. The Alx1 protein is highly conserved among euechinoid sea urchins and is closely related to the Cart1/Alx3/Alx4 family of vertebrate homeodomain proteins. In vertebrates, these proteins regulate the formation...

...Shimian Qu; S. Craig Tucker; Qi Zhao; Benoit deCrombrugghe; Ron Wisdom ABSTRACT Alx4 and Cart1 are closely related members of the family of transcription factors that contain the paired-type homeodomain. In contrast to other types of homeodomains, the paired-type homeodomain has been shown...

... that restricts ZPA formation to the posterior limb bud mesenchyme. * Author for correspondence 25 07 1997 © 1997 by Company of Biologists 1997 polydactyly Zone of Polarizing Activity gastroschesis mouse Alx4 limb Sonic hedgehog In the vertebrate limb, patterning...