...Yongjun Yin; Jeffrey R. Koenitzer; Debabrata Patra; Sabine Dietmann; Peter Bayguinov; Andrew S. Hagan; David M. Ornitz ABSTRACT Alveologenesis is the final stage of lung development in which the internal surface area of the lung is increased to facilitate efficient gas exchange in the mature...

...Fatima N. Chaudhry; Nigel S. Michki; Dain L. Shirmer; Sharon McGrath-Morrow; Lisa R. Young; David B. Frank; Jarod A. Zepp ABSTRACT Alveologenesis, the final stage in lung development, substantially remodels the distal lung, expanding the alveolar surface area for efficient gas exchange. Secondary...

... that are influenced by chemical and mechanical stimuli. Mesenchymal cells play key roles in numerous developmental processes. Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein α subunits G αq and G α11 (G αq/11 ) transmit mechanical and chemical signals to activate...

...Yinshan Fang; Hongxia Shao; Qi Wu; Neng Chun Wong; Natalie Tsong; Patricia J. Sime; Jianwen Que ABSTRACT Alveologenesis requires the coordinated modulation of the epithelial and mesenchymal compartments to generate mature alveolar saccules for efficient gas exchange. However, the molecular...

...Rongbo Li; John C. Herriges; Lin Chen; Robert P. Mecham; Xin Sun Alveologenesis, the final step of lung development, is characterized by the formation of millions of alveolar septa that constitute the vast gas-exchange surface area. The genetic network driving alveologenesis is poorly understood...