... methylation. Nevertheless, the role of TET1 in demethylating ICRs in the female germline and in controlling allele-specific expression remains unknown. Here, we examined ICR-specific DNA methylation in Tet1 −/− germ cells and ascertained whether abnormal ICR methylation impacted imprinted gene expression...

... diseases. Our ability to interrogate causes of imprinting instability has been hindered by the absence of suitable model systems. Here, we describe a Dlk1 knock-in reporter mouse that enables single-cell visualization of allele-specific expression and prospective isolation of cells, simultaneously. We show...

... 1 12 2008 © 2009. 2009 Embryonic stem (ES) cells Epigenetics Genomic imprinting ES in vitro imprinting model ncRNA Histone modifications DNA methylation Allele-specific expression Airn ( Air ) To study imprinted expression at the Igf2r cluster we used two inbred 129...