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Keywords: Aging
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Journal Articles
Journal: Development
Development (2020) 147 (11): dev175786.
Published: 11 June 2020
...Juan I. Bravo; Séverine Nozownik; Prakroothi S. Danthi; Bérénice A. Benayoun ABSTRACT Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging...
Journal Articles
Journal: Development
Development (2020) 147 (9): dev183855.
Published: 05 May 2020
... age. Here, we use time-lapse imaging and single cell RNA-seq to measure activation trajectories and rates in young and aged MuSCs. We find that the activation trajectory is conserved in aged cells, and we develop effective machine-learning classifiers for cell age. Using cell-behavior analysis and RNA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev151837.
Published: 01 October 2019
...Muriel Rhinn; Birgit Ritschka; William M. Keyes ABSTRACT Cellular senescence is a state comprising an essentially irreversible proliferative arrest combined with phenotypic changes and pronounced secretory activity. Although senescence has long been linked with aging, recent studies have uncovered...
Journal Articles
Journal: Development
Development (2019) 146 (4): dev168120.
Published: 18 February 2019
...Yuka Nakatani; Hiroshi Kiyonari; Toru Kondo ABSTRACT The self-renewal activity of neural stem cells (NSCs) has been suggested to decrease with aging, resulting in age-dependent declines in brain function, such as presbyopia and memory loss. The molecular mechanisms underlying decreases in NSC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev167197.
Published: 25 October 2018
.... Summary: Examination of gene expression and morphological changes in mouse skeletal muscle during prepuberty demonstrates that satellite cell-derived myonuclear accretion contributes to prepubertal hypertrophic skeletal muscle growth. Aging Extracellular matrix Hypertrophy Mouse Musculoskeletal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (8): dev143420.
Published: 13 April 2018
...Hongbo Zhang; Keir J. Menzies; Johan Auwerx ABSTRACT The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial role of mitochondrial-linked signaling in stem cell function has come to light and the...
Journal Articles
Journal: Development
Development (2018) 145 (1): dev153544.
Published: 08 January 2018
... declines with age. Increasing Wnt activity upon loss of dickkopf 1 can counteract both the decline of newborn neurons and the age-related cognitive decline. However, the precise cellular changes underlying the age-related decline or its rescue are fundamentally not understood. The present study combines a...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (4): 612–623.
Published: 15 February 2017
...Helen Marie Tauc; Alpaslan Tasdogan; Patrick Meyer; Petra Pandur Adult stem cells uphold a delicate balance between quiescent and active states, a deregulation of which can lead to age-associated diseases such as cancer. In Drosophila , intestinal stem cell (ISC) proliferation is tightly regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (19): 3429–3433.
Published: 01 October 2016
...Anna Bigas; Claudia Waskow In June 2016, around 200 scientists from all over the world gathered at EMBL headquarters in Heidelberg, Germany to discuss the recent advances in hematopoietic stem cells from three different angles: developmental, adulthood and aging. The meeting, aptly named...
Journal Articles
Journal: Development
Development (2015) 142 (18): 3085–3089.
Published: 15 September 2015
... stem cell (iPSC) differentiation protocols yield cells that typically show the behavior of fetal stage cells. Acknowledging aging as a contributing factor in late-onset neurodegenerative disorders represents an important step on the road towards faithfully recreating these diseases in vitro . Here, we...
Journal Articles
Journal: Development
Development (2015) 142 (9): 1572–1581.
Published: 01 May 2015
... in degenerative conditions such as aging, can impair muscle regeneration. Here, we review recent discoveries of the intrinsic and extrinsic factors that regulate satellite cell behaviour in regenerating and degenerating muscles. * Author for correspondence ( mrudnicki@ohri.ca ) Competing...
Journal Articles
Journal: Development
Development (2013) 140 (17): 3601–3612.
Published: 01 September 2013
... discussions and for reading the manuscript. Thanks to M. Kacergis for technical support in all aspects of the project. Funding This work was supported by a New Scholar in Aging Award from the Ellison Medical Foundation [A.S.]; a National Institutes of Health (NIH) Career Development Award...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 2059–2068.
Published: 15 May 2011
...Xinxin Huang; Hui Zhang; Hong Zhang Like other biological processes, aging is regulated by genetic pathways. However, it remains largely unknown whether aging is determined by an innate programmed timing mechanism and, if so, how this timer is linked to the mechanisms that control developmental...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 3897–3906.
Published: 15 August 2004
..., metabolism and life span. Given that the TOR and insulin pathways are highly conserved among divergent species, crosstalk between these pathways via a DAF-16 ortholog may exist in humans. In C. elegans , DAF-16 functions downstream of the AGE-1 phosphoinositide 3-kinase (PI3K), which mediates daf-2...
Journal Articles
Journal: Development
Development (2004) 131 (11): 2565–2575.
Published: 01 June 2004
... reduction in C. elegans life span was observed, with accompanying signs of premature aging, such as earlier accumulation of lipofuscin and tissue deterioration in the head. In addition,various developmental defects, including small, dumpy, ruptured, transparent body, growth arrest and bag of worms, were...
Journal Articles
Journal: Development
Development (2004) 131 (8): 1765–1776.
Published: 15 April 2004
.... Fundamental insights into how genes and environment influence metazoan metabolism, development and aging have emerged from a genetic dissection of C. elegans diapause. Despite its simplicity, C. elegans possesses a remarkable endocrine system that regulates choice of arrest at the third larval stage (L3...
Journal Articles
Journal: Development
Development (2002) 129 (1): 221–231.
Published: 01 January 2002
... longevity at 15°C ( Fig. 2 B). The daf-16 mutation, which suppresses the longevity phenotypes of daf-2 and age-1 , failed to suppress the longevity of daf-9(e1406) in two independent trials. The mean and maximum life spans were not significantly reduced in either trial ( Fig. 2 B; Table 1 ). daf-3...