...Zaleena Akheralie; Tanner J. Scidmore; Bret J. Pearson ABSTRACT The planarian Schmidtea mediterranea is a well-established model of adult regeneration, which is dependent on a large population of adult stem cells called neoblasts. Upon amputation, planarians undergo transcriptional wounding...

.... Highlighted Article: Wnt/β-catenin signalling stimulation promotes the exit from quiescence and differentiation of adult hippocampal neural stem cells but is dispensable for homeostatic neurogenesis in the dentate gyrus of young mice. Adult neurogenesis Adult stem cells Quiescence Wnt...

...Jarno Drost; Hans Clevers ABSTRACT Adult stem cells from a variety of organs can be expanded long-term in vitro as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time...

... ( [email protected] ) Competing interests The authors declare no competing financial interests. © 2014. Published by The Company of Biologists Ltd 2014 Adult stem cells Hedgehog signaling Homeostasis During vertebrate development, hedgehog (HH) signaling plays an essential role...

... Transcription factor 7-like 1 protein Adult stem cells Lineage tracing Mouse Tcf3 (also known as Tcf7-like 1 or Tcf7l1 ) is a member of the Lef/Tcf family, a group of transcription factors with important roles in development, stem cell homeostasis and malignancy. Tcf3 is a crucial regulator...

...Shrividhya Srinivasan; Anthony P. Mahowald; Margaret T. Fuller The stem cell niche provides a supportive microenvironment to maintain adult stem cells in their undifferentiated state. Adhesion between adult stem cells and niche cells or the local basement membrane ensures retention of stem cells...

...Carolina N. Perdigoto; Francois Schweisguth; Allison J. Bardin Tight regulation of self-renewal and differentiation of adult stem cells ensures that tissues are properly maintained. In the Drosophila intestine, both commitment, i.e. exit from self-renewal, and terminal differentiation...

[email protected] ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 27 5 2011 © 2011. Fgf Nkx2.5 Adult stem cells Haemangioblast Cross-antagonism Reprogramming Zebrafish...

... Chondrocyte maturation Transit amplification Adult stem cells Chick Mouse © 2011. 15 11 2010 Competing interests statement * Author for correspondence ( [email protected] ) Fig. 4. Fzd signaling inhibits CamkII activity. Sections of growth plate...

...Allison J. Bardin; Carolina N. Perdigoto; Tony D. Southall; Andrea H. Brand; François Schweisguth Adult stem cells maintain tissue homeostasis by controlling the proper balance of stem cell self-renewal and differentiation. The adult midgut of Drosophila contains multipotent intestinal stem cells...

...,and for the origins of stem cells in the adult heart. * Author for correspondence (e-mail: [email protected] ) 24 2 2009 © 2009. 2009 Myelopoiesis Cardiogenesis GATA factors Second heart field Haemangioblasts Transcriptional regulation Evolution Adult stem cells Zebrafish...

...., 1997 ), which is found associated to the vasculature and displays hematopoietic potential in vitro ( Asakura et al., 2002 ). Muscle adult stem cells also exhibit hematopoietic capacity in vivo( Gussoni et al., 1999 ; Howell et al., 2002 ; Jackson et al., 1999 ). The markers CD34 and Sca1...