...Bruce D. Kohorn; Frances D. H. Zorensky; Jacob Dexter-Meldrum; Salem Chabout; Gregory Mouille; Susan Kohorn ABSTRACT Plant growth, morphogenesis and development involve cellular adhesion, a process dependent on the composition and structure of the extracellular matrix or cell wall. Pectin...

... predicts an adhesion-dominant intercalation mechanism. Genetic experiments support this prediction, revealing a role for adhesion through the Nephrin proteins Roughest and Hibris. Second, we found that cone cell intercalation is regulated by the Notch pathway. Third, we show that endocytosis is required...

... migration, cells undergo cycles of coordinated attachment and detachment from the extracellular matrix (ECM). Embryonic migration processes that require cell-ECM attachment are dependent on the integrin family of adhesion receptors. Precise regulation of integrin-mediated adhesion is important for many...

... tissue morphology during embryonic development by governing key elements of cell shape, adhesion, migration and differentiation. * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare no competing or financial interests...

...Helen Neuert; Petra Deing; Karin Krukkert; Elke Naffin; Georg Steffes; Benjamin Risse; Marion Silies; Christian Klämbt ABSTRACT The development of tissues and organs requires close interaction of cells. To achieve this, cells express adhesion proteins such as the neural cell adhesion molecule (NCAM...

...Carola Dewitz; Xin Duan; Niccolò Zampieri ABSTRACT Type I and type II classical cadherins constitute a family of cell adhesion molecules expressed in complex combinatorial profiles in the nervous system, suggesting that a cadherin code implements specific adhesive recognition events that control...

...Vanesa Jiménez-Amilburu; Didier Y. R. Stainier ABSTRACT Tissue morphogenesis requires changes in cell-cell adhesion as well as in cell shape and polarity. Cardiac trabeculation is a morphogenetic process essential for forming a functional ventricular wall. Here, we show that zebrafish hearts...

... mesoderm development, suggesting that RA ligand is available to the embryo earlier than previously appreciated. RARγ1 is required for cellular adhesion, as revealed by spontaneous dissociation and depletion of ncam1 mRNA in animal caps harvested from RARγ1 knockdown embryos. RARγ1 knockdown obliterates...

... at gastrulation, but how the adhesive and mechanical forces required for these movements are generated and transmitted is unclear. Traction force microscopy (TFM) was used to establish that traction stresses are limited primarily to leading edge cells in mesendoderm explants, and that these forces are balanced...

... as they are clustered at the midline, resembling other midline structures important for maintaining the bilateral organization of the neural tube. Adhesion Cell movement Midline Pituitary Chick RNA-seq Sp8 Placodes are discrete thickenings of the cranial ectoderm localized in the proximity...

... regulates not only Myosin phosphorylation but also adhesion dynamics through control of Moesin phosphorylation, showing that Mbs coordinates actomyosin contractility with cell-cell adhesion during amnioserosa morphogenesis. * Author for correspondence ( [email protected] ) Competing...

... the connectivity of neurons in brain circuits. Interacting cells Development Adhesion Morphogenesis Cell communication National Institutes of Health 10.13039/100000002 1R21NS08485 Cell-cell contacts are fundamental to the development and function of multicellular organisms. Cell...

...Iván Mestres; Jen-Zen Chuang; Federico Calegari; Cecilia Conde; Ching-Hwa Sung Emerging evidence suggests that endocytic trafficking of adhesion proteins plays a crucial role in neuronal migration during neocortical development. However, molecular insights into these processes remain elusive. Here...

..., differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismal development. In particular, LPA signalling has been shown to affect fertility and reproduction, formation of the nervous system, and development of the vasculature. Here and in the accompanying...

... and subcortical neurons in the developing brain. T-cad is primarily expressed in axons, but it is also expressed in cell bodies or dendrites at early developmental stages. Other adhesion molecules have also been shown to be expressed specifically in axons. In the developing cortex, L1 and TAG-1, immunoglobulin...

... cells. Different cell types regulate contractility and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellular organizations, as well as a variety of resulting tissue shape changes. Understanding both the common themes and the variations in apical constriction...

... by application of a novel time-lapse confocal microscopy method along with immunofluorescence and electron microscopy. We show that, during cell division, daughter chondrocytes establish a cell-cell adhesion surface enriched in cadherins and β-catenin. Rearrangement into columns occurs concomitant with expansion...

... generated by such actomyosin networks are precisely regulated and are transmitted to the cell cortex of adjacent cells and to the extracellular environment by adhesive clusters comprising cadherins or integrins. Here, and in the accompanying poster, we provide an overview of the mechanics, principles...

... that coordinate morphogenesis and the mechanisms that translate these signals into tissue shape changes are not well understood. Here, we demonstrate that changes in intercellular adhesion mediated by the transmembrane protein Fasciclin III (FasIII) represent a key mediator of morphogenesis. Using the embryonic...

... mRNA transcripts. Single-cell global gene expression profiling showed that undifferentiated cells fell into two clusters delineated by expression of DLL1 and its binding partner syntenin. The DLL1 + cluster had elevated expression of genes associated with endocytosis, integrin-mediated adhesion...