... in an integrated mechanochemical signaling system to ultimately control cardiomyocyte proliferation in the newborn mouse heart. Rho-associated kinase Nonmuscle myosin Heart Cardiomyocyte Cell adhesion Cadherin Integrin Adherens junctions Focal adhesions Fibronectin Yap Mouse National...

... in Xenopus . Lmo7 Actomyosin contractility Non-muscle myosin II Adherens junctions Morphogenesis Xenopus ectoderm National Institutes of Health R35GM122492 Apical constriction, or reduction in size of the apical domain, underlies a variety of morphogenetic processes during...

... be influenced by the size, composition or dynamics of contacts between membranes. The initiation of Notch signalling in the Drosophila embryo occurs during cellularization, when lateral cell membranes and adherens junctions are first being deposited, allowing us to investigate the importance of membrane...

... to PCP defects. Tmsb4x depletion did not preclude epidermal cell adhesion in vivo or in vitro ; however, it resulted in abnormal structural organization and stability of adherens junction (AJ) due to defects in filamentous (F)-actin and G-actin distribution. In cultured keratinocytes, TMSB4X depletion...

... it occurs via rapid remodeling of adherens junctions or focal adhesion assembly, or both, remains poorly understood. Furthermore, how endothelial cell adhesion is controlled in particular tissues and under different conditions remains unexplored. Here, we have identified an unexpected role...

... (WC). To study this, we examined adherens junctions during WC in Drosophila larvae. β-Catenin is reduced at the lateral cell-cell junctions of wound-edge epidermal cells in the early healing stages. Destruction complex components, including Ck1α, GSK3β and β-TrCP, suppress β-catenin levels...

... required for regulation of adherens junction (AJ) stability and dynamics. However, much less is known about how such phosphorylation of E-Cadherin regulates AJ formation and dynamics in vivo . In this report, we generated an extensive array of Drosophila E-Cadherin (DE-Cad) endogenous knock-in alleles...

... retinal organisation and rescues most vav mutant phenotypes. Second, using live imaging in the pupal retina, we observe that vav mutant cells do not form stable adherens junctions, causing various defects, such as recruitment of extra primary pigment cells. In agreement with this role in junction dynamics...

... pupal lattice, in which hexagonal ommatidial units pack tightly. This process involves the fine regulation of adherens junctions (AJs) and of adhesive E-Cadherin (E-Cad) complexes. Localized accumulation of Bazooka (Baz), the Drosophila PAR3 homolog, has emerged as a critical step to specify where new E...

...Pierre-Marie Le Droguen; Sandra Claret; Antoine Guichet; Véronique Brodu Epithelial remodelling is an essential mechanism for organogenesis, during which cells change shape and position while maintaining contact with each other. Adherens junctions (AJs) mediate stable intercellular cohesion...

... migration Endocytosis EEA1 RAB5 PAR3 Lethal giant larva Tight junctions Adherens junctions Interkinetic nuclear migration Midbrain Chick During neurulation, a flat neural plate rolls up to form a closed neural tube. This process involves diverse cell behaviors...

... but persisted elsewhere in the NT where it was enriched in apical adherens junctions ( Fig. 2A-C ). First, we noticed that neuroepithelial cells rounded up,losing their elongated pseudostratified morphology( Fig. 2B,D ), which was likely to have resulted from homogeneous membrane distribution of the transfected...

... are not essential. † Authors for correspondence (e-mail: brookem@andrew.cmu.edu ; peifer@unc.edu ) * These authors contributed equally to this work 7 4 2006 © 2006. 2006 Mutation cluster region Familial adenomatous polyposis Adherens junctions β-Catenin Many...

... mechanisms underlie the establishment of pioneer and later myotomal waves. © 2006. 2006 Adherens junctions Asymmetric cell division Avian embryo Cell adhesion Dermis Dermomyotome Desmin Epithelial to mesenchymal transition Muscle Myod Myf5 Pax3 Pax7 Somite...

... localises at adherens junctions of the developing photoreceptor cells. A structure-function analysis of the Mbt protein in vitro and in vivo revealed that the Mbt kinase domain and the GTPase binding domain, which specifically interacts with GTP-loaded Cdc42, are important for Mbt function. Besides...

... of cell biological and anatomical approaches, we have determined a complete morphogenetic pathway of cellular events that lead to the formation of the vulva. These events include reproducible cell divisions, migrations, remodeling of adherens junctions, cell fusions and muscle attachments. In the course...

... peripheral nervous system adherens junctions vinculin talin The neural crest exemplifies the mechanism of rapid modulation of cell adhesion during morphogenesis, and also provides a powerful paradigm for cell migration and cell differentiation (for reviews, see Le Douarin, 1982 ; Thiery et al...

...Jean-Loup Duband; Tova Volberg; Ilana Sabanay; Jean Paul Thiery; Benjamin Geiger A-CAM (adherens-junction-specific cell adhesion molecule) is a calcium-dependent adhesion molecule which is associated with intercellular adherens junctions in various tissues (Volk & Geiger, 1986, J. Cell Biol...