.... Error bars indicate s.d. in F-I. Adherens junction Adhesion Cell intercalation Epithelia Nephrins Notch Summary: Cell intercalation via intercellular junction remodeling can occur over minutes or even hours. Three pathways, adhesion, endocytosis and Notch, were found to induce...

.... Here, we report a surprising role for Scribble/Dlg in polarity initiation, placing it near the top of the network-positioning adherens junctions. Scribble and Dlg are enriched in nascent adherens junctions, are essential for adherens junction positioning and supermolecular assembly, and also play...

...Ramya Balaji; Vanessa Weichselberger; Anne-Kathrin Classen ABSTRACT How actomyosin generates forces at epithelial adherens junctions has been extensively studied. However, less is known about how a balance between internal and external forces establishes epithelial cell, tissue and organ shape. We...

... apicobasal cell polarity was unaffected, the key epithelial elements of adherens junction and cell-matrix adhesion were disrupted in the TZ of Hand2 mutant mice, indicating poorly formed epithelium. RNA-seq analysis revealed altered regulation of the contractile fiber and actin cytoskeleton, which affected...

.... During gastrulation, presumptive mesoderm cells invaginate, undergo an epithelial-to-mesenchymal state transition (EMT) and migrate upon the ectoderm. Our data show that EMT is a prolonged process in which adherens junctions progressively decrease in number throughout the migration of mesoderm cells. FGF...

... this balance, yet the interaction between signaling and receiving cells remains poorly understood. We have found that numerous nascent neurons and/or intermediate neurogenic progenitors expressing the ligand of Notch retain apical endfeet transiently at the ventricular lumen that form adherens junctions (AJs...

... Drosophila eye development, differentiated photoreceptors form clusters that rotate independently of the surrounding interommatidial cells (ICs). Here, we demonstrate that both Echinoid (Ed), an adherens junction-associated cell adhesion molecule, and Flamingo (Fmi), a PCP determinant, are endocytosed via...

... Fog G-alpha 12 G-alpha 13 Abl Cta Neural tube S2 cell Adherens junction Drosophila During embryogenesis, many morphogenetic events shape the body plan. These rely on shape changes in single cells that must be coordinated within tissues. Although the particular cell-shape changes...

... rearrangements and shape the vertebrate embryo. * Author for correspondence (e-mail: [email protected] ) 2 8 2006 © 2006. 2006 Neural tube Convergence Radial intercalation Protrusive activity Cell polarity Adherens junction Neurulation can be defined as a series...

...Michael J. Murray; Catherine M. Davidson; Neil M. Hayward; Andrea H. Brand Fes/Fer non-receptor tyrosine kinases regulate cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions. Unregulated Fes/Fer kinase activity has been shown to lead to tumours in vivo. Here...

...Fumiyasu Imai; Syu-ichi Hirai; Kazunori Akimoto; Hiromichi Koyama; Takaki Miyata; Masaharu Ogawa; Shigeru Noguchi; Toshikuni Sasaoka; Tetsuo Noda; Shigeo Ohno In developing mammalian telencephalon, the loss of adherens junctions and cell cycle exit represent crucial steps in the differentiation...

... with significant reduction in E-cadherin, Armadillo and F-actin accumulation, suggesting that not only Src signaling but also Src -dependent adherens-junction stabilization would appear likely to be essential for normal dorsal closure. Src42A and Src64 were required for Armadillo tyrosine residue phosphorylation...

... the junctional complex. Transmission electron microscopy(TEM) studies showed that the adherens junction and the tight junction were formed at the apical side of neuroepithelial cells in both the wild type and the double mutant at E8.5 ( Fig. 6B,E , arrowheads). A higher magnification shows kissing points...

...Craig R. Magie; Delia Pinto-Santini; Susan M. Parkhurst Rho GTPases are important regulators of cellular behavior through their effects on processes such as cytoskeletal organization. Here we show interactions between Drosophila Rho1 and the adherens junction components α-catenin and p120 ctn . We...

... adherens junction Drosophila escargot shotgun cadherin During embryogenesis, multiple cell types are specified and are assembled to form functional organs. This process involves cell sorting, migration of individual cells and movement of cells as a group ( Hynes and Lander, 1992 ). Cell...