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In collection:Cardiovascular development and regeneration
Pragya Sidhwani, Dena M. Leerberg, Giulia L. M. Boezio, Teresa L. Capasso, Hongbo Yang, Neil C. Chi, Beth L. Roman, Didier Y. R. Stainier, Deborah Yelon
Development (2020) 147 (12): dev185900.
Published: 17 June 2020
.... In zebrafish, we find that the OFT expands via accrual of both endocardial and myocardial cells. However, when cardiac function is disrupted, OFT endocardial growth ceases, accompanied by reduced proliferation and reduced addition of cells from adjacent vessels. The flow-responsive TGFβ receptor Acvrl1...
Includes: Supplementary data
Rita L. C. Carvalho, Leon Jonker, Marie-José Goumans, Jonas Larsson, Peter Bouwman, Stefan Karlsson, Peter ten Dijke, Helen M. Arthur, Christine L. Mummery
Development (2004) 131 (24): 6237–6247.
Published: 15 December 2004
... ( Guttmacher et al., 1995 ; Shovlin and Letarte, 1999 ), whereas telangiectases appear later and are known to occur in the lung, brain and liver of individuals with HHTs. There are two distinct genes responsible for HHT, endoglin( McAllister et al., 1994 ),which is mutated in HHT1, and ALK1 ( ACVRL1...
Beth L. Roman, Van N. Pham, Nathan D. Lawson, Magdalena Kulik, Sarah Childs, Arne C. Lekven, Deborah M. Garrity, Randall T. Moon, Mark C. Fishman, Robert J. Lechleider, Brant M. Weinstein
Development (2002) 129 (12): 3009–3019.
Published: 15 June 2002
... number in specific cranial vessels. We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Alk1), a TGFβ type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants. Thus, vbg provides a model for the human autosomal...
Includes: Multimedia, Supplementary data