.... In zebrafish, we find that the OFT expands via accrual of both endocardial and myocardial cells. However, when cardiac function is disrupted, OFT endocardial growth ceases, accompanied by reduced proliferation and reduced addition of cells from adjacent vessels. The flow-responsive TGFβ receptor Acvrl1...

..., The Netherlands † Present address: Center for Regenerative Medicine and Technology,Massachusetts General Hospital, Boston, MA 02114, USA 13 10 2004 © 2004. 2004 HHT TGFβ Endoglin Yolk sac ACVRL1 Hereditary haemorrhagic telangietasia (HHT), also known as Rendu-Osler-Weber...

... number in specific cranial vessels. We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Alk1), a TGFβ type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants. Thus, vbg provides a model for the human autosomal...