...Zhenyi Liu; Eric Brunskill; Scott Boyle; Shuang Chen; Mustafa Turkoz; Yuxuan Guo; Rachel Grant; Raphael Kopan We have previously described the creation and analysis of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::Cre LO , that marked cells experiencing...

... a covalently linked cholesterol moiety. Although the role of the cholesterol group of Hedgehog remains unclear, it has been suggested to be dispensable for the its long-range activity in Drosophila . Here, we provide data in three different epithelia - ventral and dorsal embryonic ectoderm, and larval imaginal...

...Hongjuan Zhao; Michael L. Nonet ABSTRACT We have characterized how perturbations of normal synaptic activity influence the morphology of cholinergic SAB motor neurons that innervate head muscle in C. elegans . Mutations disrupting components of the presynaptic release apparatus, acetylcholine (ACh...

... is gradually refined into an accurate retinotectal map by a process that depends on afferent activity. On their way to the tectum, many regenerating axons make erroneous choices between the two arms (brachia) of the optic tract. However, since they commonly possess divergent collateral branches, a secondary...