...-oncogenes regulates cell-cell contacts . Development 143 , 623 - 634 . 10.1242/dev.127993 Burke , T. A. , Christensen , J. R. , Barone , E. , Suarez , C. , Sirotkin , V. and Kovar , D. R. ( 2014 ). Homeostatic actin cytoskeleton networks are regulated by assembly...

... and lipid studies reveal that the lipid droplet-associated Adipose Triglyceride Lipase provides the substrate for prostaglandin production during Drosophila follicle development, ultimately regulating actin remodeling and promoting fertility. Actin cytoskeleton Lipid droplets Prostaglandin...

... the effects of Tmsb4x depletion on both AJs and PCP. Our results provide insights into the regulation of the actin pool and its involvement in AJ function and PCP establishment. Actin cytoskeleton Adherens junctions Epidermis Morphogenesis Planar cell polarity All experimental protocols...

... of the developing mouse embryo. Arp2/3 Melanoblasts Migration Actin cytoskeleton Skin pigmentation Tissue morphogenesis is in balance with cell migration. During development, cell movements are tightly regulated and highly coordinated in space and time. Melanocytes, the melanin producing cells...

.../Rac GTPases in nascent myotubes and effects changes in the actin cytoskeleton. FGF signals are thus essential regulators of myotube guidance that act through cytoskeletal regulatory proteins to pattern the musculoskeletal system. * Present address: Kite Pharma, El Segundo, CA 90245, USA...

...) have a dynamic actin cytoskeleton that drives their expansion to a diameter of 10 μm. Although multiple proteins have been identified as components of RCs, we lack a basic understanding of how RC proteins interact together to form and regulate the RC cytoskeleton. Thus, here, we optimized a procedure...

... mutagenesis of HtsRC revealed its requirement in the recruitment of the ring canal F-actin cytoskeleton. We present genetic evidence consistent with HtsRC being the CRL3 Kelch substrate, as well as biochemical evidence indicating that HtsRC is ubiquitylated and degraded by the proteasome. Finally, we identify...

... 2016. Published by The Company of Biologists Ltd 2016 Summary:   In utero electroporation coupled with real-time imaging reveals that actin cytoskeleton dynamics during neuronal migration are controlled by the cooperation of reelin and cofilin. Neuronal migration Cofilin phosphorylation...

... © 2014. Published by The Company of Biologists Ltd 2014 Convergence and extension Non-canonical Wnt signaling Zebrafish Mutated in colorectal cancer (Mcc) Actin cytoskeleton Mutated in colorectal cancer ( MCC ) was first identified in 1991 as a candidate tumor suppressor gene...

..., and on the other hand identify singed as a new target of Breathless signal, establishing a link between guidance cues, the actin cytoskeleton and tracheal morphogenesis. sn was known to be expressed in different embryonic tissues ( Zanet et al., 2009 ), and Berkeley Drosophila Genome Project reported...

... membrane-enriched lipid essential for actin cytoskeleton remodeling in many cellular events, including phagocytosis ( Botelho et al., 2004 ). We constructed a reporter for PtdIns(4,5) P 2 by tagging the pleckstrin homology (PH) domain of human phospholipase C δ1, a high-affinity PtdIns(4,5) P 2 -binding...

... for a feedback mechanism that could regulate tissue growth ( Aegerter-Wilmsen et al., 2007 ; Hufnagel et al., 2007 ). The tension exerted by neighboring cells might be sensed at the cell membrane by the actin cytoskeleton and translated to the regulation of cell proliferation through the Hpo signaling pathway...

... Lasp Oskar Actin cytoskeleton Drosophila In Drosophila melanogaster , maternally provided mRNAs and proteins are transported from the nurse cells into the growing oocyte and stored until they are required at later stages of development. oskar mRNA, which encodes the posterior...

... of active Rho1 at the apical side organises the Actin cytoskeleton and promotes high Myosin II accumulation/activity in this region,leading to a contractile Actin-Myosin based force to produce a wedge-shaped cell. Our data show that spatial restriction of Rho1 activity is achieved by distinct mechanisms...

..., with high directionality even at low fibronectin concentration. This was associated with increased vinculin immunostaining. These findings suggest alterations in cell surface linkage to the actin cytoskeleton may contribute to the changes in cell motility exhibited by the Cx43α1KO and CMV43 CNCs. Previous...

...Tamás Matusek; Alexandre Djiane; Ferenc Jankovics; Damian Brunner; Marek Mlodzik; József Mihály Formins are involved in a wide range of cellular processes that require the remodeling of the actin cytoskeleton. Here, we have analyzed a novel Drosophila formin, belonging to the recently described...

... tubules demonstrates that its activity is required to regulate the reorganisation of the actin cytoskeleton during the process of convergent extension. In addition, overexpression of cv-c in the developing tubules gives rise to actin-associated membrane extensions. Thus, Cv-c function is required...

... Actin cytoskeleton Growth cone attraction Extracellular guidance cues, their receptors on the growth cone surface,and intracellular effectors function together to regulate directional axon extension ( Dent and Gertler,2003 ; Guan and Rao,2003 ; Huber et al.,2003 ; Lee and Van Vactor,2003...

... and embryos lacking maternal and zygotic Pten function display phenotypes consistent with a function for PTEN in the organization of the actin cytoskeleton. In freshly laid eggs, the germ plasm determinants oskar mRNA and Vasa are not localized properly to the posterior cytocortex and pole cells do not form...

... 2004 ©2005. 2005 Lysophosphatidic acid Actin cytoskeleton G-protein-coupled receptor Xenopus The actin skeleton is required for many cellular processes, including cytokinesis, endocytosis and exocytosis; cell shape and polarity; cell process formation; and motility ( Jacinto...