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Keywords: Actin cytoskeleton
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Journal Articles
Journal: Development
Development (2024) 151 (6): dev201757.
Published: 27 March 2024
... eye development Morphogenesis 3D cytoskeletal network Apical–basal polarity Actin cytoskeleton Epithelial patterning Cell–cell interactions Feedback mechanism Photoreceptor Pigment cell National Institutes of Health http://dx.doi.org/10.13039/100000002 R01 EY021459 T32 GM007281...
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Reproductive biology
Journal: Development
Development (2023) 150 (20): dev201516.
Published: 8 June 2023
... by increases in triglycerides and sterol esters (K,L), neutral lipids stored in LDs. Massive remodeling of the nurse cell actin cytoskeleton begins when LDs are highly abundant (E-H). The cortical actin thickens and actin bundles extend from the membrane to the nucleus during S10B (H). During S11, actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev193425.
Published: 11 December 2020
... polarity and epidermal morphogenesis. Actin cytoskeleton Adherens junctions Epidermis Morphogenesis Planar cell polarity Proper polarization of cells and cellular structures along the plane of a tissue, or planar cell polarity (PCP), is essential for embryonic development and tissue...
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Journal Articles
Journal: Development
Development (2020) 147 (22): dev194555.
Published: 15 November 2020
... branched actin assembly is indispensable for melanoblasts populating the skin of the developing mouse embryo. Arp2/3 Melanoblasts Migration Actin cytoskeleton Skin pigmentation Tissue morphogenesis is in balance with cell migration. During development, cell movements are tightly regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev183624.
Published: 7 February 2020
.../Rac GTPases in nascent myotubes and effects changes in the actin cytoskeleton. FGF signals are thus essential regulators of myotube guidance that act through cytoskeletal regulatory proteins to pattern the musculoskeletal system. * Present address: Kite Pharma, El Segundo, CA 90245, USA...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev176644.
Published: 18 July 2019
...) have a dynamic actin cytoskeleton that drives their expansion to a diameter of 10 μm. Although multiple proteins have been identified as components of RCs, we lack a basic understanding of how RC proteins interact together to form and regulate the RC cytoskeleton. Thus, here, we optimized a procedure...
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Journal Articles
Journal: Development
Development (2019) 146 (1): dev169219.
Published: 2 January 2019
... mutagenesis of HtsRC revealed its requirement in the recruitment of the ring canal F-actin cytoskeleton. We present genetic evidence consistent with HtsRC being the CRL3 Kelch substrate, as well as biochemical evidence indicating that HtsRC is ubiquitylated and degraded by the proteasome. Finally, we identify...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (6): 1029–1040.
Published: 15 March 2016
... free barbed F-actin ends, which might initiate the branching activity of the Arp2/3 complex ( Svitkina and Borisy, 1999 ; Pantaloni et al., 2000 ; Volkmann et al., 2001 ; Amann and Pollard, 2001 ; Ichetovkin et al., 2002 ). Ongoing reorganization of the actin cytoskeleton in S3A neurons might...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (4): 929–939.
Published: 15 February 2014
..., and on the other hand identify singed as a new target of Breathless signal, establishing a link between guidance cues, the actin cytoskeleton and tracheal morphogenesis. An f riboprobe was generated using the following primers: forward, 5′-AGATACAGATCGCCCAGCAG-3′; reverse, 5′-TGTGATTTGCCAGACATGGT-3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (15): 3230–3243.
Published: 1 August 2013
... membrane-enriched lipid essential for actin cytoskeleton remodeling in many cellular events, including phagocytosis ( Botelho et al., 2004 ). We constructed a reporter for PtdIns(4,5) P 2 by tagging the pleckstrin homology (PH) domain of human phospholipase C δ1, a high-affinity PtdIns(4,5) P 2 -binding...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (11): 2337–2346.
Published: 1 June 2011
... signaling pathway Actin cytoskeleton Drosophila discs epithelia The conserved Hippo (Hpo) signal transduction pathway has emerged as a crucial regulator of tissue size in both Drosophila and mammals ( Edgar, 2006 ). In Drosophila , the Hpo pathway comprises a kinase cascade in which the Hpo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (1): 95–105.
Published: 1 January 2009
... organization. Genes Dev. 8 , 2986 -2995. Lantz, V. A., Clemens, S. E. and Miller, K. G. ( 1999 ). The actin cytoskeleton is required for maintenance of posterior pole plasm components in the Drosophila embryo. Mech. Dev. 85 , 111 -122. Lehmann, R. and Nusslein-Volhard, C. ( 1986 ). Abdominal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (21): 4257–4267.
Published: 1 November 2006
... μm in B-D. DT,tracheal dorsal trunk; SC, spiracular chamber. To visualise the Actin cytoskeleton during the invagination process, we expressed GFP-Actin in the spiracle invaginating cells and followed in vivo cell shape changes. GFP-Actin preferentially accumulated at the apical side...
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Journal Articles
Journal: Development
Development (2006) 133 (18): 3629–3639.
Published: 15 September 2006
.... * Author for correspondence (e-mail: loc@nhlbi.nih.gov ) 20 7 2006 © 2006. 2006 Connexin 43 Neural crest cell Focal contact Actin cytoskeleton Cell motility Neural crest cells are ectomesenchymal cells derived by epithelialmesenchyme cell transformation from the dorsal...
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Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (10): 2389–2400.
Published: 15 May 2005
... tubules demonstrates that its activity is required to regulate the reorganisation of the actin cytoskeleton during the process of convergent extension. In addition, overexpression of cv-c in the developing tubules gives rise to actin-associated membrane extensions. Thus, Cv-c function is required...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (8): 1983–1994.
Published: 15 April 2005
...: regulators of the actin cytoskeleton and cell migration. Annu. Rev. Cell Dev. Biol. 19 , 541 -564. Kwiatkowski, A. V., Gertler, F. B. and Loureiro, J. J. ( 2003 ). Function and regulation of Ena/VASP proteins. Trends Cell Biol. 13 , 386 -392. Lanier, L. M. and Gertler, F. B. ( 2000 ). From Abl...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (7): 1675–1686.
Published: 1 April 2005
... and embryos lacking maternal and zygotic Pten function display phenotypes consistent with a function for PTEN in the organization of the actin cytoskeleton. In freshly laid eggs, the germ plasm determinants oskar mRNA and Vasa are not localized properly to the posterior cytocortex and pole cells do not form...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 805–816.
Published: 15 February 2005
... effects are most likely due to an expanding number of LPA-mediated morphogenetic events during later stages. Fig. 9. Zygotic expression of LPA receptors is necessary to maintain the density of the actin cytoskeleton at the late blastula stage and for normal Xenopus development. (A) Depletion...