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Keywords: Actin
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Journal Articles
Journal: Development
Development (2021) 148 (18): dev198507.
Published: 29 April 2021
... reconstruction Actin Development Image processing Nucleus Directional left-right (LR) asymmetry, which is evident in the external and internal morphology of many animals, is genetically determined ( Davison, 2020 ; Hobert et al., 2002 ; Inaki et al., 2018a , b ; Kuroda, 2015 ). Recent studies show...
Journal Articles
Journal: Development
Development (2020) 147 (17): dev186502.
Published: 02 September 2020
... summarizes the mechanics of network assembly, and provides insights into cell ratcheting, force transmission and pulsatility. Myosin Actin Morphogenesis Pulsatility Ratcheting Any observer who has watched an animal embryo develop has seen that the tissues that make up the embryo show a...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev179168.
Published: 31 July 2020
... crossover between sister PVD dendrites. Our genetic analysis suggests that FMI-1 promotes transient F-actin assembly at the tips of contacting sister dendrites to facilitate their efficient retraction during self-avoidance events, probably by interacting with WSP-1/N-WASP. Mutations of vang-1 , which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184069.
Published: 20 April 2020
... were found in corticofugal projections and axonal growth cones in Klc1 −/− mice. By live-cell imaging of CB1R-eGFP we characterized the axonal transport of CB1R vesicles and described the defects in transport that arise after KLC1 deletion. Cofilin activation, which is necessary for actin dynamics...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev171397.
Published: 04 April 2019
... a dynamic filopodium-like branchlet. The mechanisms underlying the initiation of dendrite branchlets are therefore crucial to the shaping of dendrites. Through in vivo time-lapse imaging of the subcellular localization of actin during the process of branching of Drosophila larva sensory neurons...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (7): dev164129.
Published: 04 April 2019
...Ashley A. DeAguero; Lizzet Castillo; Sandy T. Oas; Kaveh Kiani; Anton L. Bryantsev; Richard M. Cripps ABSTRACT Serum response factor (SRF) has an established role in controlling actin homeostasis in mammalian cells, yet its role in non-vertebrate muscle development has remained enigmatic. Here, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171280.
Published: 04 February 2019
...Hong-Hui Wang; Yu Zhang; Feng Tang; Meng-Hao Pan; Xiang Wan; Xiao-Han Li; Shao-Chen Sun ABSTRACT Cytoskeletal dynamics are involved in multiple cellular processes during oocyte meiosis, including spindle organization, actin-based spindle migration and polar body extrusion. Here, we report that the...
Journal Articles
Journal: Development
Development (2018) 145 (24): dev168922.
Published: 12 December 2018
... actomyosin activity, induces apical constriction, which is required for bottle cell formation during Xenopus gastrulation. Apical constriction Bottle cell Gastrulation RhoGEF Actin Myosin Xenopus Apical constriction refers to an active reduction of cell apical surface area that then...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev161117.
Published: 30 July 2018
... specifically decipher the mechanisms controlling collective cell migration. Here, we identify the Drosophila Insulin/Insulin-like growth factor signalling (IIS) pathway as a key regulator in controlling actin dynamics in border cells, independently of its function in growth control. Loss of IIS activity blocks...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (11): dev164988.
Published: 30 May 2018
..., distributing in a PAR-dependent manner along the anterior–posterior (A–P) embryonic axis. PIP 2 cortical structures overlap with F-actin, and coincide with the actin regulators RHO-1 and CDC-42, as well as ECT-2. Particle image velocimetry analysis revealed that PIP 2 and F-actin cortical movements are coupled...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4588–4603.
Published: 15 December 2017
...Rob van der Kammen; Ji-Ying Song; Iris de Rink; Hans Janssen; Stefania Madonna; Claudia Scarponi; Cristina Albanesi; Wim Brugman; Metello Innocenti The Arp2/3 complex assembles branched actin filaments, which are key to many cellular processes, but its organismal roles remain poorly understood...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (23): 4249–4260.
Published: 01 December 2017
... 2017 http://www.biologists.com/user-licence-1-1/ Summary: This Review emphasizes the role of the actomyosin meshwork in determining the forces that operate within and between cells and their environment to shape and organize cells and tissues. Actin Contractility Morphogenesis...
Journal Articles
Journal: Development
Development (2016) 143 (20): 3806–3816.
Published: 15 October 2016
... associated with diseases including cancer. However, how the undesired activation of PKC is prevented during development remains poorly understood. We have previously shown that a protein kinase, IKKε, is active at the growing bristle tip and regulates actin bundle organization during Drosophila bristle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (15): 2741–2752.
Published: 01 August 2016
... development. However, the cytoskeletal mechanisms that drive radial glial outgrowth and maintain RGC polarity remain poorly understood. Here, we show that the Arp2/3 complex – the unique actin nucleator that produces branched actin networks – plays essential roles in RGC polarity and morphogenesis. Disruption...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (23): 4107–4118.
Published: 01 December 2015
... responsible for mediating RC tyrosine phosphorylation, and loss of Src64 causes a reduction in RC diameter within germline cysts. Mechanistically, we show that Src64 controls an actin network around the RCs that depends on Abl and the Rac/SCAR/Arp2/3 pathway. The actin network around RCs is required for...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (15): 2704–2718.
Published: 01 August 2015
... altered dorsal organizer and mesendodermal gene expression, due to impaired dorsal determinant transport and Nodal signaling. Mechanistically, MZ dchs1b phenotypes can be explained in part by defective actin or microtubule networks, which appear bundled in mutants. Accordingly, disruption of actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (14): 2478–2486.
Published: 15 July 2015
... distally pointing cuticular hairs. Using in vivo imaging we found that, early in hair growth, cells have multiple actin bundles and hairs that subsequently fuse into a single growing hair. The downstream PCP gene multiple wing hairs ( mwh ) plays a key role in this process and acts to antagonize the actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (12): 2173–2183.
Published: 15 June 2015
... Armadillo Actin Time-lapse movie Parental RNAi Transient protein expression In most insects, the nuclei of the fertilized egg divide multiple times and move to the cortex before cellularization starts. During cellularization, plasma membrane ingresses between the nuclei and encloses them within...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (10): 1879–1884.
Published: 15 May 2015
... technique to an intact living vertebrate organism. We generated zebrafish lines expressing chromobodies that trace the major cytoskeletal component actin and the cell cycle marker PCNA with spatial and temporal specificity. Using these chromobodies, we captured full localization dynamics of the endogenous...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (7): 1305–1314.
Published: 01 April 2015
... columnar pseudostratified tube over the course of ∼24 h. Apical F-actin is known to be important for neural tube closure, but the precise roles of actin dynamics in the neural epithelium are not known. To determine how the organization of the neural epithelium and neural tube closure are affected when...
Includes: Supplementary data