... axon patterning in Drosophila by local modulation of Abl tyrosine kinase signaling, via direct interactions with the Abl co-factors Disabled and Trio. Here, we show that Notch-Abl axonal signaling requires both of the proteolytic cleavage events that initiate canonical Notch signaling. We further show...

...Ramakrishnan Kannan; Jeong-Kuen Song; Tatiana Karpova; Akanni Clarke; Madhuri Shivalkar; Benjamin Wang; Lyudmila Kotlyanskaya; Irina Kuzina; Qun Gu; Edward Giniger ABSTRACT The Abl tyrosine kinase signaling network controls cell migration, epithelial organization, axon patterning and other aspects...

...Tzu-Yang Lin; Chiu-Hui Huang; Hsiu-Hua Kao; Gan-Guang Liou; Shih-Rung Yeh; Chih-Ming Cheng; Mei-Hsin Chen; Rong-Long Pan; Jyh-Lyh Juang Abl tyrosine kinase (Abl) regulates axon guidance by modulating actin dynamics. Abelson interacting protein (Abi), originally identified as a kinase substrate...

... the existence of additional ventral furrow regulators. Here, we report the identification of Abelson kinase (Abl) as a novel ventral furrow regulator. We find that Abl acts apically to suppress the accumulation of both Enabled (Ena) and actin in mesodermal cells during ventral furrow formation. Further, RhoGEF2...

...David J. Forsthoefel; Eric C. Liebl; Peter A. Kolodziej; Mark A. Seeger The attractive Netrin receptor Frazzled (Fra), and the signaling molecules Abelson tyrosine kinase (Abl), the guanine nucleotide-exchange factor Trio,and the Abl substrate Enabled (Ena), all regulate axon pathfinding...

...Eric C. Liebl; R. Grant Rowe; David J. Forsthoefel; Amanda L. Stammler; Erica R. Schmidt; Michelle Turski; Mark A. Seeger Two novel dosage-sensitive modifiers of the Abelson tyrosine kinase( Abl ) mutant phenotype have been identified. Amalgam (Ama) is a secreted protein that interacts...