...Emin Maltepe; Geoffrey W. Krampitz; Kelly M. Okazaki; Kristy Red-Horse; Winifred Mak; M. Celeste Simon; Susan J. Fisher Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor composed of HIFα and the arylhydrocarbon receptor nuclear translocator(ARNT/HIF1β). Previously, we have...

...Diana L. Ramírez-Bergeron; Anja Runge; Karen D. Cowden Dahl; Hans Joerg Fehling; Gordon Keller; M. Celeste Simon Hypoxia Inducible Factor (HIF), consisting of HIF1α and ARNT(HIF1β) subunits, activates multiple genes in response to oxygen(O 2 ) deprivation. Arnt –/– mice exhibit substantial defects...

... to the nucleus, where it dimerizes with another bHLH- PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt). Ahr:Arnt heterodimers then activate transcription of target genes that encode enzymes involved in metabolizing aryl hydrocarbons. In this report, we present evidence that Ss functions...

... and Trachealess derives from transcriptional activation of their genes in their respective lineages, not from extracellular signaling. One implication of the Drosophila studies is that Tgo does not form transcriptionally active homodimers during embryogenesis. Studies with mammalian Arnt have shown...

... and Trachealess activate transcription by forming dimers with the Drosophila Tango protein that is an orthologue of the mammalian Arnt protein. Both cell culture and in vivo studies show that a DNA enhancer element acts as a binding site for both Single-minded∷Tango and Trachealess∷Tango heterodimers...

... , cloned the Drosophila ARNT gene ( dARNT ), and showed biochemical and genetic evidence that breathless expression in developing trachea is regulated by direct interactions between TRACHEA-LESS/dARNT heterodimers and three central midline elements (TACGTGs) situated in the minimum enhancer region. Our...