... at the pIIa-pIIb interface, the basal pool of Notch is reported to be the main contributor for Notch activation in the pIIa cell. Intra-lineage signalling requires appropriate apico-basal targeting of Notch, its ligand Delta and its trafficking partner Sanpodo. We have previously reported that AP-1...

... factors, but how different signalling pathways act in a cell type-specific fashion is poorly understood. Here, we studied the regulatory role of the AP-1 transcription factor family in blood development using embryonic stem cell differentiation coupled with genome-wide transcription factor binding...

... elongation deficiencies lead to life-threatening congenital heart defects, the variables controlling the initiation, rate and duration of myocardial accretion remain obscure. Here, we demonstrate that the AP-1 transcription factor, Fos-like antigen 2 (Fosl2), potentiates the rate of myocardial accretion from...

... of clathrin, its adaptor AP-1 and the AP-1 interactor SOAP-1 induced a basolateral localisation of E-cad without affecting the apico-basal diffusion barrier. We further found that SOAP-1 controls AP-1 localisation, and that AP-1 is required for clathrin recruitment. Finally, we also show that AP-1 controls E...

... was only recently appreciated and is thought to be limited to basolateral transport. Here, an unbiased RNAi-based tubulogenesis screen identifies a role of clathrin (CHC-1) and its AP-1 adaptor in apical polarity during de novo lumenal membrane biogenesis in the C. elegans intestine. We show that CHC-1/AP...

... adaptor AP-1 in the C. elegans intestine, we found that AP-1 is required for epithelial polarity maintenance. Depletion of AP-1 subunits does not affect epithelial polarity establishment or the formation of the intestinal lumen. However, the loss of AP-1 affects the polarised distribution of both apical...

... induction. * Author for correspondence (e-mail: [email protected] ) 4 12 2008 © 2009. 2009 Neural induction Syndecan-4 FGF PKC Rac JNK AP-1 c-Fos The `default model' of neural induction proposes that neural development occurs as a result of the inhibition of BMP...

..., T. K., Aubin, J. E. and Rodan, G. A. ( 1997 ). Osteogenic protein-1 up-regulation of the collagen X promoter activity is mediated by a MEF-2-like sequence and requires an adjacent AP-1 sequence. Mol. Endocrinol. 11 , 1832 -1845. Hess, J., Hartenstein, B., Teurich, S., Schmidt, D.,Schorpp...

...Martin Schreiber; Zhao-Qi Wang; Wolfram Jochum; Ingrid Fetka; Candace Elliott; Erwin F. Wagner ABSTRACT Fra1 is an immediate-early gene encoding a member of the AP-1 transcription factor family, which has diverse roles in development and oncogenesis. To determine the function of Fra1 in mouse...

...Dominique Thépot; Jonathan B. Weitzman; Jacqueline Barra; Dominique Segretain; Marie-Georges Stinnakre; Charles Babinet; Moshe Yaniv ABSTRACT JunD is one of three mammalian Jun proteins that contribute to the AP-1 transcription factor complex. Distinct regulation and functions have been proposed...

... pathological conditions. Several recent studies, using both expression and functional assays, have implicated the transcription factor, AP-1, in the regulation of programmed cell death, and specifically implicate the genes c- fos and c- jun , as well as some other family members. If the products of the c- fos...

...Susan C. Barnett; Marta Rosario; Arthur Doyle; Anna Kilbey; Archie Lovatt; David A. F. Gillespie ABSTRACT AP-1 is an ubiquitous transcription factor which is composed of the Jun and Fos proto-oncogene proteins and is thought to play a role in both cell proliferation and differentiation. We have...