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Keywords: AMPK
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Journal Articles
Journal: Development
Development (2018) 145 (23): dev166876.
Published: 28 November 2018
... in mutants that have lost the energy sensor AMP-activated protein kinase (AMPK) or the insulin/IGF-1 signaling (IIS) negative regulator DAF-18/PTEN. We report that DBL-1/BMP works upstream of IIS to promote agonistic insulin-like peptides during L1 arrest. However, the abnormal Q cell divisions that occur...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1235–1241.
Published: 1 April 2017
.../ Summary: In mice, bridging of paired MEF2C-bound MEF2 sites in a cardiac enhancer of the Prkaa2 gene by the transcriptional co-activator myocardin promotes cooperativity between the two homotypic elements. AMPK MEF2 Prkaa2 Mouse Myocardin Transcription We thank M. Parmacek, R...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (4): 661–670.
Published: 15 February 2010
... embryos. We demonstrate that most of par-4 -dependent regulation of germline stem cell (GSC) quiescence occurs through AMPK, whereby PAR-4 requires STRD-1 to phosphorylate and activate AMPK. Consistent with this, even though AMPK plays a major role in the regulation of cell proliferation, like strd-1...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (4): 611–619.
Published: 15 February 2006
...Patrick Narbonne; Richard Roy In C. elegans , reduced insulin-like signalling induces developmental quiescence, reproductive delay and lifespan extension. We show here that the C. elegans orthologues of LKB1 and AMPK cooperate during conditions of reduced insulin-like signalling to establish cell...