... + macrophages in Tlr4 f/f and Tlr4 f/f ;Cdh5-Cre embryos following ex vivo stimulation with LPS. Dams were injected with tamoxifen (TAM) at E9.5. (H) Percentage of TNF + macrophages in vehicle and LPS-stimulated explanted E10.5 Tlr4 f/f and Tlr4 f/f ;Cdh5-Cre ERT AGM regions. n =3-6...

... , A. M. , Ure , J. , Zhao , S. , Zuyev , S. , Ansell , J. and Medvinsky , A. ( 2002 ). Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac...

... and can give rise to all blood cell lineages. The AGM region is an important intra-embryonic site of HSC development and a wealth of evidence indicates that HSCs emerge from the endothelium of the embryonic dorsal aorta and extra-embryonic large arteries. This, however, is a stepwise process that occurs...

... key issues currently circulating in this field. * Author for correspondence ( a.medvinsky@ed.ac.uk ) Competing interests statement The authors declare no competing financial interests. © 2011. 2011 AGM region Yolk sac Placenta dHSC Pre-dHSC The ontogeny...

...Samir Taoudi; Aline M. Morrison; Hirofumi Inoue; Ruby Gribi; Janice Ure; Alexander Medvinsky The yolk sac and the para-aortic splanchnopleura/aorta-genital ridges-mesonephros (P-Sp/AGM) region are the main sites of haematopoietic activity in the mouse embryo at the pre-liver stage of development...

...Parasakthy Kumaravelu; Lilian Hook; Aline M. Morrison; Jan Ure; Suling Zhao; Sergei Zuyev; John Ansell; Alexander Medvinsky In the developing mouse embryo the first definitive(transplantable-into-the-adult) haematopoietic stem cells/long-term repopulating units (HSC/RUs) emerge in the AGM region...