... that the original work is properly attributed. Summary: Mouse Nr4a1 − / − Nr4a2 − / − embryos lack hematopoietic stem cell activity at E11.5, implicating NR4A orphan nuclear receptors in endothelial-to-hematopoietic transition, a key step in in hematopoietic stem cell specification. AGM...

... support the interpretation that the two populations are representative of the early sites of mammalian hematopoiesis. * Author for correspondence ( [email protected] ) Competing interests statement 8 6 2010 © 2010. AGM Hematopoiesis Induced pluripotent stem cell...

...Marian Peeters; Katrin Ottersbach; Karine Bollerot; Claudia Orelio; Marella de Bruijn; Mark Wijgerde; Elaine Dzierzak Hematopoiesis is initiated in several distinct tissues in the mouse conceptus. The aorta-gonad-mesonephros (AGM) region is of particular interest,as it autonomously generates...

... investigated the temporal expression of Mpl during mouse development by in situ hybridization. We found Mpl expression in the HSCs clusters emerging in the AGM region, and in the fetal liver (FL) as early as E10.5. Using Mpl -/- mice, the functional relevance of Mpl expression was tested by comparing...

... of the osteogenic, adipogenic and chondrogenic lineages, in most of the sites harboring hematopoietic cells. They first appear in the aorta-gonad-mesonephros (AGM) region at the time of HSC emergence. However, at this developmental stage, their presence is independent of HSC activity. They increase numerically...