.... * Author for correspondence ( [email protected] ) Competing interests statement 8 6 2010 © 2010. AGM Hematopoiesis Induced pluripotent stem cell Embryonic stem cells Sox17 Yolk sac Mouse The capacity of embryonic stem cells (ESCs) and induced...

...Marian Peeters; Katrin Ottersbach; Karine Bollerot; Claudia Orelio; Marella de Bruijn; Mark Wijgerde; Elaine Dzierzak Hematopoiesis is initiated in several distinct tissues in the mouse conceptus. The aorta-gonad-mesonephros (AGM) region is of particular interest,as it autonomously generates...

... investigated the temporal expression of Mpl during mouse development by in situ hybridization. We found Mpl expression in the HSCs clusters emerging in the AGM region, and in the fetal liver (FL) as early as E10.5. Using Mpl -/- mice, the functional relevance of Mpl expression was tested by comparing...

... of the osteogenic, adipogenic and chondrogenic lineages, in most of the sites harboring hematopoietic cells. They first appear in the aorta-gonad-mesonephros (AGM) region at the time of HSC emergence. However, at this developmental stage, their presence is independent of HSC activity. They increase numerically...