..., in a distribution established in the early embryo. We further show that biallelic expression of the CPM regulatory gene Tbx1 , haploinsufficient in 22q11.2 deletion syndrome patients, is required for the correct patterning of muscles with CPM-derived connective tissue. Our results suggest that CPM plays...

... into two distinct vessels(Yutzey and Kirby, 2002). Human chromosomal deletion syndromes are common causes of birth defects,but the complex and rare nature of such deletions have made a mechanistic analysis of the developmental anomalies elusive. 22q11.2 deletion syndrome(22q11DS), the most common...