...Marie A. Breau; Ahmed Dahmani; Florence Broders-Bondon; Jean-Paul Thiery; Sylvie Dufour Integrins are the major adhesive receptors for extracellular matrix and have various roles in development. To determine their role in cell migration,the gene encoding the β1 integrin subunit ( Itgb1...

...Claudia S. Barros; Tom Nguyen; Kathryn S. R. Spencer; Akiko Nishiyama; Holly Colognato; Ulrich Müller Oligodendrocytes in the central nervous system (CNS) produce myelin sheaths that insulate axons to ensure fast propagation of action potentials. β1 integrins regulate the myelination of peripheral...

... system, we removed β1 integrins in the neural crest cells when they emerge from the neural tube. β1-null enteric neural crest cells fail to colonise the gut completely, leading to an aganglionosis of the descending colon, which resembles the human Hirschsprung's disease. Moreover,β1-null enteric neural...

... deficient in β1 were able to migrate normally in vivo in wild-type/β1-null chimeric embryos( Fässler and Meyer, 1995 ; Hirsch et al., 1998 ). This suggested that migration in general was not dependent on β1 integrins. An alternative explanation, however, could be the low percentage of chimerism used...