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Keywords: β-catenin
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Journal Articles
Journal: Development
Development (2021) 148 (11): dev199091.
Published: 01 June 2021
... epithelial and mesenchymal cells. Here, we fate-mapped Wnt-responsive epithelial and mesenchymal cells in mice and found that Wnt activation resulted in opposing cell fates. In the post-mitotic cochlear epithelium, Wnt activation via β-catenin stabilization induced clusters of proliferative cells that...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev198101.
Published: 29 April 2021
...Bo Wang; Xiaozhi Rong; Yumei Zhou; Yunzhang Liu; Jiqin Sun; Beibei Zhao; Bei Deng; Lei Lu; Ling Lu; Yun Li; Jianfeng Zhou ABSTRACT A key step in the activation of canonical Wnt signaling is the interaction between β-catenin and Tcf/Lefs that forms the transcription activation complex and...
Includes: Supplementary data
Journal Articles
In collection:
Human development
Journal: Development
Development (2020) 147 (21): dev189597.
Published: 31 July 2020
... tumors arise from the dysregulation of normal development. β-Catenin activation is observed in a significant proportion of WTs; however, much remains to be understood about how it contributes to tumorigenesis. Although activating β-catenin mutations are observed in both blastema and stromal components of...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev185108.
Published: 12 April 2020
... novel dorsal and ventral hindgut domains, and show that ventrolateral hindgut cells populate the majority of the colonic epithelium. A Wnt3a-β-catenin-Sp5/8 pathway, which is active in the dorsal hindgut endoderm, is required for hindgut extension and colon formation. Interestingly, the absence of Wnt...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2020) 147 (6): dev183814.
Published: 30 March 2020
... molecular signals ensure ovary versus testis differentiation with canonical Wnt/β-catenin signals paramount for promoting the ovary pathway. Notably, few direct downstream targets have been identified. We report that Wnt/β-catenin signaling directly stimulates Irx3 and Irx5 transcription in the developing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (20): dev175133.
Published: 02 October 2019
... (WC). To study this, we examined adherens junctions during WC in Drosophila larvae. β-Catenin is reduced at the lateral cell-cell junctions of wound-edge epidermal cells in the early healing stages. Destruction complex components, including Ck1α, GSK3β and β-TrCP, suppress β-catenin levels in the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev164145.
Published: 02 July 2019
...Daniel B. Lybrand; Misha Naiman; Jessie May Laumann; Mitzi Boardman; Samuel Petshow; Kevin Hansen; Gregory Scott; Marcel Wehrli ABSTRACT The central regulator of the Wnt/β-catenin pathway is the Axin/APC/GSK3β destruction complex (DC), which, under unstimulated conditions, targets cytoplasmic β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (2): dev166454.
Published: 16 January 2019
..., localized Fgf10 expression maintains distal Sox9 -expressing epithelial progenitors and promotes basal cell differentiation in the cartilaginous airways. Mesenchymal Fgf10 expression is induced by Wnt signaling but inhibited by Shh signaling, and epithelial Fgf10 signaling activates β-catenin signaling. The...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev166975.
Published: 30 November 2018
... evidence for synergy between cx43 and smp . Moreover, knockdown of Smp increases the evx1 expression, similar to cx43 knockdown. Previous studies have shown that Smp is required for the nuclear localization of β-catenin. Indeed, β-catenin activity is required for segment length, and is reduced in both sof...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (14): dev159368.
Published: 17 July 2018
... restricts dorsoanterior development in Xenopus . We found that Notch1 has ventralizing properties and abolishes the dorsalizing activity of β-catenin by reducing its steady state levels, in a process that does not require β-catenin phosphorylation by glycogen synthase kinase 3β. In the present work, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (4): dev157677.
Published: 16 February 2018
... voicing. The molecular mechanisms that instruct vocal fold formation are rarely studied. Here, we show, for the first time, that conditional inactivation of the gene encoding β-catenin in the primitive laryngopharyngeal epithelium leads to failure in separation of the vocal folds, which approximates the...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (22): 4173–4182.
Published: 15 November 2017
...Xinchao Pan; Courtney M. Karner; Thomas J. Carroll For organs to achieve their proper size, the processes of stem cell renewal and differentiation must be tightly regulated. We previously showed that in the developing kidney, Wnt9b regulates distinct β-catenin-dependent transcriptional programs in...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3031–3041.
Published: 01 September 2017
... showed that the Wnt signaling pathway is involved in oviductal epithelial homoeostasis. By developing two triple-transgenic mouse models, we showed that Wnt/β-catenin signaling is essential for self-renewal as well as the differentiation of secretory cells. In summary, our results provide mechanistic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1283–1295.
Published: 01 April 2017
... the genome is poorly understood. Here we identified the transcriptomes of Xenopus foregut and hindgut progenitors, which are conserved with mammals. Using RNA-seq and ChIP-seq we show that BMP/Smad1 regulates dorsal-ventral gene expression in both the endoderm and mesoderm, whereas Wnt/β-catenin acts...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1242–1248.
Published: 01 April 2017
...Yi-Jiun Chen; Juan Huang; Lynn Huang; Erin Austin; Yang Hong Phosphorylation of a highly conserved serine cluster in the intracellular domain of E-Cadherin is essential for binding to β-Catenin in vitro . In cultured cells, phosphorylation of specific serine residues within the cluster is also...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4167–4172.
Published: 15 November 2016
...Kaoru S. Imai; Clare Hudson; Izumi Oda-Ishii; Hitoyoshi Yasuo; Yutaka Satou Many animal embryos use nuclear β-catenin (nβ-catenin) during the segregation of endomesoderm (or endoderm) from ectoderm. This mechanism is thus likely to be evolutionarily ancient. In the ascidian embryo, nβ-catenin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4149–4160.
Published: 15 November 2016
...Miquel Sureda-Gómez; José M. Martín-Durán; Teresa Adell The β-catenin-dependent Wnt pathway exerts multiple context-dependent roles in embryonic and adult tissues. In planarians, β-catenin-1 is thought to specify posterior identities through the generation of an anteroposterior gradient. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (14): 2522–2535.
Published: 15 July 2016
... proliferation and Wnt/β-catenin activity. Between P2 and P50, fibroblast density declined throughout the dermis and clones of fibroblasts became more dispersed. This correlated with a decline in fibroblasts expressing a TOPGFP reporter of Wnt activation. Surprisingly, between P2 and P50 there was no difference...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (12): 2194–2205.
Published: 15 June 2016
... influenced by Wnt/β-catenin signalling. Using two in vivo models, we show that Wnt/β-catenin signalling is transiently inhibited at the time of NC delamination. In attempting to define the mechanism underlying this inhibition, we found that the scaffold proteins Dact1 and Dact2, which are expressed in pre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (11): 1914–1925.
Published: 01 June 2016
...Yukio Nakamura; Eduardo de Paiva Alves; Gert Jan C. Veenstra; Stefan Hoppler Key signalling pathways, such as canonical Wnt/β-catenin signalling, operate repeatedly to regulate tissue- and stage-specific transcriptional responses during development. Although recruitment of nuclear β-catenin to...
Includes: Supplementary data