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Journal Articles

Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage

Luca Giovanni Di Giovannantonio, Dario Acampora, Daniela Omodei, Vincenzo Nigro, Pasquale Barba, Elisa Barbieri, Ian Chambers, Antonio Simeone

Development (2021) 148 (10): dev199166.

https://doi.org/10.1242/dev.199166

Published: 17 May 2021

View article titled, Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage

Includes: Supplementary data

Journal Articles

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity

Luca G. Di Giovannantonio, Michela Di Salvio, Daniela Omodei, Nilima Prakash, Wolfgang Wurst, Alessandra Pierani, Dario Acampora, Antonio Simeone

Development (2014) 141 (2): 377–388.

https://doi.org/10.1242/dev.102954

Published: 15 January 2014

View article titled, Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity

Includes: Supplementary data

Journal Articles

The transcription factor Otx2 regulates choroid plexus development and function

Pia A. Johansson, Martin Irmler, Dario Acampora, Johannes Beckers, Antonio Simeone, Magdalena Götz

Development (2013) 140 (5): 1055–1066.

https://doi.org/10.1242/dev.090860

Published: 1 March 2013

View article titled, The transcription factor Otx2 regulates choroid plexus development and function

Includes: Supplementary data

Journal Articles

Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition

Dario Acampora, Luca G. Di Giovannantonio, Antonio Simeone

Development (2013) 140 (1): 43–55.

https://doi.org/10.1242/dev.085290

Published: 1 January 2013

View article titled, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition

Includes: Supplementary data

Journal Articles

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Nilima Prakash, Eduardo Puelles, Kristine Freude, Dietrich Trümbach, Daniela Omodei, Michela Di Salvio, Lori Sussel, Johan Ericson, Maike Sander, Antonio Simeone, Wolfgang Wurst

Development (2009) 136 (15): 2545–2555.

https://doi.org/10.1242/dev.031781

Published: 1 August 2009

View article titled, Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Includes: Supplementary data

Journal Articles

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

Daniela Omodei, Dario Acampora, Pietro Mancuso, Nilima Prakash, Luca Giovanni Di Giovannantonio, Wolfgang Wurst, Antonio Simeone

Development (2008) 135 (20): 3459–3470.

https://doi.org/10.1242/dev.027003

Published: 15 October 2008

View article titled, Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

Includes: Supplementary data

Journal Articles

Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants

Isabelle Foucher, Marina Mione, Antonio Simeone, Dario Acampora, Laure Bally-Cuif, Corinne Houart

Development (2006) 133 (10): 1891–1900.

https://doi.org/10.1242/dev.02352

Published: 15 May 2006

View article titled, Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants

Includes: Supplementary data

Journal Articles

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

Gundula Griesel, Dieter Treichel, Patrick Collombat, Jens Krull, Andreas Zembrzycki, Willem M. R. van den Akker, Peter Gruss, Antonio Simeone, Ahmed Mansouri

Development (2006) 133 (9): 1779–1787.

https://doi.org/10.1242/dev.02326

Published: 1 May 2006

View article titled, Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

Includes: Supplementary data

Journal Articles

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

Nilima Prakash, Claude Brodski, Thorsten Naserke, Eduardo Puelles, Robindra Gogoi, Anita Hall, Markus Panhuysen, Diego Echevarria, Lori Sussel, Daniela M. Vogt Weisenhorn, Salvador Martinez, Ernest Arenas, Antonio Simeone, Wolfgang Wurst

Development (2006) 133 (1): 89–98.

https://doi.org/10.1242/dev.02181

Published: 1 January 2006

View article titled, A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

Includes: Supplementary data

Journal Articles

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

Eduardo Puelles, Alessandro Annino, Francesca Tuorto, Alessandro Usiello, Dario Acampora, Thomas Czerny, Claude Brodski, Siew-Lan Ang, Wolfgang Wurst, Antonio Simeone

Development (2004) 131 (9): 2037–2048.

https://doi.org/10.1242/dev.01107

Published: 1 May 2004

View article titled, Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

Journal Articles

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2

Juan Pedro Martinez-Barbera, Massimo Signore, Pietro Pilo Boyl, Eduardo Puelles, Dario Acampora, Robin Gogoi, Frank Schubert, Andrew Lumsden, Antonio Simeone

Development (2001) 128 (23): 4789–4800.

https://doi.org/10.1242/dev.128.23.4789

Published: 1 December 2001

View article titled, Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2

Journal Articles

OTD/OTX2 functional equivalence depends on 5′ and 3′ UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation

Dario Acampora, Pietro Pilo Boyl, Massimo Signore, Juan Pedro Martinez-Barbera, Cristina Ilengo, Eduardo Puelles, Alessandro Annino, Heinrich Reichert, Giorgio Corte, Antonio Simeone

Development (2001) 128 (23): 4801–4813.

https://doi.org/10.1242/dev.128.23.4801

Published: 1 December 2001

View article titled, OTD/OTX2 functional equivalence depends on 5′ and 3′ UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation

Journal Articles

Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3′ UTR

Pietro Pilo Boyl, Massimo Signore, Dario Acampora, Juan Pedro Martinez-Barbera, Cristina Ilengo, Alessandro Annino, Giorgio Corte, Antonio Simeone

Development (2001) 128 (15): 2989–3000.

https://doi.org/10.1242/dev.128.15.2989

Published: 1 August 2001

View article titled, Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3′ UTR

Journal Articles

Otx genes are required for tissue specification in the developing eye

Juan Ramon Martinez-Morales, Massimo Signore, Dario Acampora, Antonio Simeone, Paola Bovolenta

Development (2001) 128 (11): 2019–2030.

https://doi.org/10.1242/dev.128.11.2019

Published: 1 June 2001

View article titled, Otx genes are required for tissue specification in the developing eye

Journal Articles

Craniofacial, vestibular and bone defects in mice lacking the Distal-less -related gene Dlx5

Dario Acampora, Giorgio R. Merlo, Laura Paleari, Barbara Zerega, Maria Pia Postiglione, Stefano Mantero, Eva Bober, Ottavia Barbieri, Antonio Simeone, Giovanni Levi

Development (1999) 126 (17): 3795–3809.

https://doi.org/10.1242/dev.126.17.3795

Published: 1 September 1999

View article titled, Craniofacial, vestibular and bone defects in mice lacking the Distal-less -related gene Dlx5

Journal Articles

Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon

Matías Hidalgo-Sánchez, Antonio Simeone, Rosa-Magda Alvarado-Mallart

Development (1999) 126 (14): 3191–3203.

https://doi.org/10.1242/dev.126.14.3191

Published: 15 July 1999

View article titled, Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon

Journal Articles

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear

Hakim Morsli, Francesca Tuorto, Daniel Choo, Maria Pia Postiglione, Antonio Simeone, Doris K. Wu

Development (1999) 126 (11): 2335–2343.

https://doi.org/10.1242/dev.126.11.2335

Published: 1 June 1999

View article titled, Otx1 and Otx2 activities are required for the normal development of the mouse inner ear

Journal Articles

Differential transcriptional control as the major molecular event in generating Otx1 − / − and Otx2 − / − divergent phenotypes

Dario Acampora, Virginia Avantaggiato, Francesca Tuorto, Paolo Barone, Marzia Perera, Daniel Choo, Doris Wu, Giorgio Corte, Antonio Simeone

Development (1999) 126 (7): 1417–1426.

https://doi.org/10.1242/dev.126.7.1417

Published: 1 April 1999

View article titled, Differential transcriptional control as the major molecular event in generating Otx1 − / − and Otx2 − / − divergent phenotypes

Journal Articles

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation

Dario Acampora, Virginia Avantaggiato, Francesca Tuorto, Paola Briata, Giorgio Corte, Antonio Simeone

Development (1998) 125 (24): 5091–5104.

https://doi.org/10.1242/dev.125.24.5091

Published: 15 December 1998

View article titled, Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation

Journal Articles

Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development

Dario Acampora, Virginia Avantaggiato, Francesca Tuorto, Paolo Barone, Heinrich Reichert, Robert Finkelstein, Antonio Simeone

Development (1998) 125 (9): 1691–1702.

https://doi.org/10.1242/dev.125.9.1691

Published: 1 May 1998

View article titled, Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development

NARROW

Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage

Otx2 cell-autonomously determines dorsal mesencephalon versus cerebellum fate independently of isthmic organizing activity

The transcription factor Otx2 regulates choroid plexus development and function

Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon

Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants

Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border

A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo

Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain

Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2

OTD/OTX2 functional equivalence depends on 5′ and 3′ UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation

Forebrain and midbrain development requires epiblast-restricted Otx2 translational control mediated by its 3′ UTR

Otx genes are required for tissue specification in the developing eye

Craniofacial, vestibular and bone defects in mice lacking the Distal-less -related gene Dlx5

Fgf8 and Gbx2 induction concomitant with Otx2 repression is correlated with midbrain-hindbrain fate of caudal prosencephalon

Otx1 and Otx2 activities are required for the normal development of the mouse inner ear

Differential transcriptional control as the major molecular event in generating Otx1 − / − and Otx2 − / − divergent phenotypes

Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation

Murine Otx1 and Drosophila otd genes share conserved genetic functions required in invertebrate and vertebrate brain development

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