Issues

Summary: This Review explores roles of the nucleolus in mammalian development, with a particular focus on genome organisation and chromatin regulation.

Summary: Klf2 and Klf17 control the exit of blastula stem cells from pluripotency and restrict the boundaries of the neural plate border and neural crest domains in Xenopus.

Highlighted Article: A novel apical-out endometrial organoid with stromal cells established under ECM-free conditions, enabling the recapitulation and real-time observation of the implantation process in three dimensions by co-culturing with blastocysts.

Summary: Kinesin-5 modulates microtubule sliding in neurons, acting as a brake to ensure precise axon pathfinding during Drosophila neuronal development.

Summary: An investigation of the consequences of Cajal-Retzius cell depletion, versus reelin loss, during cerebral cortex development in mice.

Summary: Migrating neural crest cells use Ptk7 to locally restrict the activity of the RhoGEF Trio to the activation of RhoA at cell-cell contact sites.

Summary: Analysis of zebrafish embryo and explant models demonstrates that temporal dynamics of morphogen signaling ratios distinguish between tissue-specific morphogenetic programs during vertebrate body plan formation.

Summary: N-cadherin knockdown in chick trigeminal placode cells reveals the continued role of N-cadherin during trigeminal ganglion development, affecting cell interactions, axon outgrowth and target innervation.

Highlighted Article: Non-professional phagocytes are crucial for clearing dying cells and maintaining tissue homeostasis. Here, we show that GATA factor Srp is essential for promoting phagocytosis in non-professional phagocytes during Drosophila oogenesis.

Summary: A new experimental pipeline for optogenetic control of Nodal signaling in zebrafish embryos raises the possibility to explore systematically how Nodal signaling patterns guide embryonic development..