Issues

Summary: Stem-cell-based embryo models provide a powerful tool with which to study early human development, partially mimicking peri-implantation stage embryos and offering insights into lineage differentiation, self-organization and morphogenesis.

Highlighted Article: Analysis of C. elegans muscle activity during development identifies involvement of two innexins and two DEG/ENaC channels and establishes that the three germ layers play a crucial role in ensuring the dynamic and progressive lengthening of the embryo.

Summary: Molecular imaging and single-cell transcriptomics of the chicken lung identify morphogenic processes and cell types underlying its unidirectional airflow.

Highlighted Article: Analysis of T-cell migration in developing zebrafish demonstrating that T cells employ tissue-specific migration strategies to migrate efficiently through the host.

Summary: In response to dietary stress, the Drosophila pseudokinase Tribbles (Trib) translocates to the membrane to block Akt activation and mutation of the conserved pseudokinase activation loop dominantly disrupts translocation.

Summary: Genetic analysis in mice identifies Nectin3 and Rac1 as regulators of PCP-directed axon guidance in the cochlea, advancing our understanding of auditory circuit assembly.

Summary: Gαi2 regulates cranial neural crest cell migration during development by interacting with EB1 to control microtubule dynamics and cell polarity.

Summary: PPARG is required for Shh expression in the basal and intermediate cell layer of the mouse ureteric epithelium and for expression of many genes in the superficial layer, ensuring the formation of a three-layered, quiescent urothelium.

Summary: Genetic and pharmacological manipulation reveal that Gq/11 is a signaling mediator acting downstream of Endothelin 1 and Endothelin Receptor Type A that drives tissue patterning for all lower jaw structures in zebrafish.