Issues

Summary: In this Spotlight, we provide an introduction to machine learning for developmental biologists interested in incorporating machine learning techniques into their research.

Highlighted Article: Recurring mechanical strain focusing at topological defect sites in regenerating Hydra suggests a mechanochemical feedback loop linking fiber organization, tissue mechanics, and morphogen dynamics in head organizer formation.

Summary: Loss of Khdrbs1 activates p53 and impairs liver regeneration after severe liver injury in zebrafish.

Summary: In mouse spermatogonial stem cells, CDKN1C acts downstream of TRP53 and collaborates with AURKB, an essential molecule for maintaining the spindle assembly checkpoint, to uphold the euploidy.

Summary: This paper describes a new model for gene regulation during heart regeneration where an enhancer is repurposed from one cardiac domain to activate a different gene during regeneration.

Summary: Demonstration of an autonomous role of Antp in guiding adult muscle precursors during Drosophila myogenesis reveals a Hox function beyond maintenance and preservation of structures.

Highlighted Article: During early development, zebrafish have a unique dendritic cell population that does not derive from HSC and displays reduced dependence on flt3 compared to the conventional HSC-derived dendritic cells.

Summary: A computational model of cardiomyocyte proliferation is developed and validated against experiments from the literature. A predicted YAP-cMyc axis is validated in data from cells and mice.

Highlighted Article: A novel method for reconstructing spatio-temporal gene expression patterns in internally developing embryos, providing a tool to explore developmental processes and generate high-quality data for computational modeling.