Issues

Summary: Development's publisher, The Company of Biologists, is celebrating its 100th birthday. Commemorating this anniversary, I discuss Development's history since launching as Journal of Embryology and Experimental Morphology.

Summary: This Review provides a comprehensive overview of the mechanisms underlying the assembly of cells into functional tubes and how failures in these processes can lead to disease.

Summary: Long-term time-lapse imaging and computational analyses reveal that cell division dynamics drive the de novo formation of single cell-derived multicellular meristems during sex-type conversion in Ceratopteris gametophytes.

Summary: Comparative histology of murids, genetic lineage tracing, and characterization of the short ear mouse strain reveals the cellular origin and maturation sequence of ear pinna tissues.

Summary: An investigation of the relationship between ETT and ARF4, and canonical and ETT-mediated auxin signalling machineries in Arabidopsis and Capsella reveals conserved functions in Brassicaceae with distinct fruit shapes.

Summary: We demonstrate, in vivo, a requirement for BMP signalling in fetal ovarian germ cell meiosis, and reveal that timely mitosis-to-meiosis transition requires both STRA8 and BMP signalling.

Summary: Epithelial SHH and WNTs are crucial signals for the proliferation and differentiation of the lamina propria in the fetal and early postnatal murine ureter. Absence of BMP4 signaling segregates the lamina propria from the adjacent smooth muscle cell layer.

Summary: Mettl3-deficient mice reveal that the loss of RNA m⁶A modification-induced acute inflammation activates acute megakaryopoiesis, but impairs its final maturation through the inhibition of IGF1 expression during fetal hematopoiesis.

Summary: A multiplexed in vivo CRISPR screening approach demonstrates the utility of pooled perturbation screening in chick embryos, identifying involvement of the super elongation complex component MLLT3 in caudal neural tissue specification.