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ANNIVERSARY ARTICLE
Anniversary article

REVIEW

Summary: This Review summarizes the current understanding of plant gamete development, cell cycle regulation, quiescence, and fertilization-triggered reactivation.

HUMAN DEVELOPMENT

Summary: Analysis of human cortical organoids reveals that NEUROG1 lineages prevail early and NEUROG2 lineages later, and that NEUROG2 targets include COL genes and PPP1R17, a human-accelerated region-associated gene.

RESEARCH REPORT

Highlighted Article: A sequence motif in the intracellular region of the atypical cadherin Fat2 is required for the rotation of Drosophila egg chambers, but is dispensable for egg chamber elongation.

RESEARCH ARTICLES

Highlighted Article: This study explains the role of Nup107 in maternal-to-zygotic transition through primary miR427 nuclear export.

Summary: Canonical Wnt is the signal from the extra-embryonic area opaca that induces and maintains the neighbouring marginal zone of the chick embryo, crucial for positioning the primitive streak.

Summary: sox10-dependent neural crest cells restrain production of anti-hypercalcemic hormones to enable the massive influx of calcium needed to initiate bone mineralization in developing fish.

Summary: Mouse genetics and single-cell transcriptomics reveal a FGF-WNT signaling circuit that regulates closure of the anterior fontanelle, a soft spot in the infant skull.

Highlighted Article: A muscle cell specification program that controls all specifically expressed genes has been documented from eggs to larvae of an ascidian.

Summary: A SOX17-binding cis-regulatory element in transcription start site 2 of Sox17 forms a positive autoregulatory feedback loop necessary for gallbladder and extra-hepatic bile duct formation.

Summary: Partial loss of H3K27me3 correlated with developmental and proapoptotic gene upregulation underlies abnormal spermatogonial stem cell maintenance and differentiation in cryptorchid testis in mice.

TECHNIQUES AND RESOURCES

Summary: Optimized life cycle, in combination with efficient gene-editing approaches, facilitates the establishment of genetic tools in N. vectensis, an emerging model for environmental stress response, regeneration and longevity.

Summary: Male and female nuclei fuse to form the zygotic nucleus in angiosperms. A time-course single-cell transcriptome analysis reveals gene expression profiles during nuclear fusion in rice zygotes.

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