Issues

Summary: This Development at a Glance article provides an overview of astrocyte ontogeny and morphogenesis, highlighting mechanisms that regulate the development of astrocytes, the most abundant glial cells in the central nervous system.

Summary: 5-HT1 receptors selectively promote early optic nerve regrowth in zebrafish and are dispensable during development, and serotonin receptor-dependent modulation instructs regenerating optic nerve axons toward the brain in vivo.

Summary: Single-cell photoconversion of emerging hematopoietic precursor cells and transcriptomics unravel the diversity of hematopoietic stem and progenitor cell populations and homing in developmental niches in toto, during zebrafish development.

Summary: The early Drosophila pioneer factors Zelda and GAGA factor undergo complementary dynamics, with Zelda binding decreasing over time, and GAF first binding to high-affinity clusters, then to low-affinity sites.

Highlighted Article: Genetic lineage tracing and expression analyses reveal insights into the developmental lineage of smooth muscle cells in the intestine and mesentery, specified by WT1 expression during mouse gastrulation.

Highlighted Article: Parvalbumin-positive interneurons use FGFR2, while somatostatin-positive interneurons use FGFR1/2, responding to distinct FGF ligands to target pyramidal neuron subdomains (soma/proximal versus distal dendrites, respectively).

Summary: Lymphatic defects of Tie1 knockout mice were largely rescued by loss of Foxo1, and the second tyrosine kinase domain of TIE1 is essential for its function in lymphatic system.

Summary: A neuronal differentiation tracing method combined with RNA-seq and DNase-seq analyses reveals the potential role of chromatin accessibility in preparing the activation of mouse neuronal genes in mature neurons.