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Cover image
Cover Image
Cover: Differentiating CFTR high expresser cells (CHEs) and their likely progenitors in rat intestinal jejunum. Notch2 (white) is found in crypt progenitors as well as differentiated villar CHEs, while Meis1 (magenta) and CFTR (yellow) are progressively upregulated along the crypt-villus axis as CHE cell differentiation progresses. See Research Article by Zagoren et al. (dev204277).
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RESEARCH HIGHLIGHTS
PERSPECTIVES
INTERVIEWS
REVIEW
Feto-placental blood vessel development
Summary: This Review contains an overview of placental vascular development and pathologies in mice and humans and highlights key remaining questions in the field.
STEM CELLS AND REGENERATION
Small molecule- and cell contact-inducible systems for controlling expression and differentiation in mouse embryonic stem cells
Identification and characterization of GAL4 upstream activation sequence-based inducible systems for use with either small molecule or juxtacrine induction to expand the cell engineering toolkit in mESCs.
RESEARCH ARTICLES
Transition paths across the epithelial-mesenchymal transition landscape are dictated by network logic
Summary: Mathematical models of gene regulatory networks make assumptions about how signals combine logically; great caution must be taken in this choice of logic, as it can lead to divergent phenotypes.
WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern
Small molecule inhibitor studies reveal for the first time that WNT signaling controls the transition of early limb bud development to the periodic digit-interdigit patterning system.
Regulation of Hippo signaling and planar cell polarity via distinct regions of the Fat intracellular domain
Summary: Using Drosophila and CRISPR/CAS9, we untangle the roles of highly conserved regions of Fat cadherins, revealing complex regulation of Hippo-mediated growth control.
Evidence of secondary Notch signaling within the rat small intestine
Summary: Rare CFTR high expresser cells, found in rats and humans but not mice, arise from the intestinal secretory lineage yet require active Notch signaling for fate specification.
Chondrocyte maturation bridges two cross-inhibitory subnetworks of the skeletal cell gene regulatory network
Visualization of the skeletal cell gene regulatory network reveals two cross-inhibitory SOX9 and RUNX2 subnetworks that interact to specify mature chondrocytes.
Endogenous glucocorticoid receptor activation modulates early-stage cell differentiation in pancreatic progenitors of mice and humans
Summary: Glucocorticoid receptor activation directs pancreatic progenitor differentiation in a context-dependent manner, driving acinar fate in mouse explants but bipotent/endocrine commitment in human in vitro models, revealing its model-specific regulatory roles.
TECHNIQUES AND RESOURCES
One probe fits all: a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes
Summary: Demonstration of OneSABER as a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes to allow diverse signal development and amplification techniques to be combined in a unified framework.
PREPRINT HIGHLIGHTS
Development presents…
Development is delighted to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are held each month with talks from postdocs applying for independent positions as part of our Pathway to Independence programme. Visit Development presents... on the Node to see which stimulating topics are coming up in the next few months.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
Browse by subject
![Development logo - Browse by subject: Explore Development's content, now easily accessible by subject area. The ad has a black background with three vibrant scientific images: a developing embryo on the left, a green plant-like structure in the center, and a gastruloid (a circular cell with a bright pink center and blue outer ring) on the right. [Blue button: browse content].](https://cob.silverchair-cdn.com/ImageLibrary/Development/Snippets/2025_05_Dev_Browse-by-subject_600x230_Snippet.png?versionId=8993)
From cardiovascular development and regeneration to tissue engineering and organoids, Development’s browse by subject archive allows you to access the latest papers (from late 2024 onwards) on a particular field of interest. In addition to our curated subject collections, these subject pages allow readers to browse a broader range of papers organised by topic.
