Issues

Summary: This Review explores how Notch signaling regulates mammalian neurogenesis through proneural gene regulation, signaling pathway crosstalk and adult neural stem cell maintenance, highlighting emerging technologies and key research gaps.

Summary: Later in inflorescence development, the florigen transcriptional complex that initiates flowering has important roles in controlling floral meristem and floral organ development.

Summary: Identification of prolonged PV interneuron maturation and distinct SST expression patterns in early postnatal and adult marmoset brain offers new insights into primate prefrontal cortex development, highlighting differences from rodent cortical maturation.

Summary: The Condensin II complex regulates cell cycle progression and erythroid differentiation, but is dispensable for nuclear condensation during terminal erythroid maturation.

Highlighted Article: Early, FGF-dependent Kupffer's vesicle progenitor cell divisions are essential for rosette formation, Kupffer's vesicle morphogenesis and proper left-right axis development in zebrafish, showing that mitotic events shape left-right organizer architecture and function.

Highlighted Article: Dystroglycan and Dystrophin function to regulate laminin deposition and glial ensheathment in the Drosophila peripheral nerve.

Summary: The Drosophila Spalt proteins regulate gene silencing through the maintenance of heterochromatic domains. Loss of Spalt alters chromatin accessibility, causes misexpression of transposable elements and generates DNA damage and alterations in the localization of chromosomes within the nucleus.

Summary: Surveying chromatin accessibility during development in the acoel Hofstenia miamia enables studies of developmental regulatory interactions and comparisons between development and regeneration.

Summary: SunTag-based single-molecule translation imaging in C. elegans enables measurement and manipulation of localized erm-1 translation dynamics, revealing its importance for development.