-
Cover image
Cover Image
Cover: Development of preimplantation mouse embryos from embryonic day (E) 3.5 to E4.5. A three-dimensional reconstruction of blastocyst nuclei stained with Hoechst33342. See Research article by Hirono et al. (dev203091).
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
EDITORIAL
The Company of Biologists: celebrating 100 years
Summary: As we begin celebrating our 100-year anniversary, we reflect on our extraordinary story so far, consider the Company's current support for our communities and prepare for some inspiring activities.
INTERVIEWS
REVIEW
A comparative view of human and mouse telencephalon inhibitory neuron development
Summary: This Review introduces conserved and distinct aspects of telencephalon inhibitory neuron development between humans and mice, offering comprehensive insights into the evolutionary diversity of neurodevelopment and its implications for brain disorders.
STEM CELLS AND REGENERATION
Maintenance of niche architecture requires actomyosin and enables proper stem cell signaling and oriented division in the Drosophila testis
Actomyosin contractility-regulated niche architecture is crucial for proper signaling and oriented division of germline stem cells.
Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue
Summary: A tango6 mutant zebrafish allele with disrupted haematopoiesis reveals that the vesicle trafficking protein Tango6 mediates haematopoietic stem and progenitor cell expansion, and definitive haematopoiesis via the Rpb2-P53-Ikzf1/Cmyb axis.
RESEARCH REPORT
Optogenetic control of cAMP oscillations reveals frequency-selective transcription factor dynamics in Dictyostelium
Summary: Controlling cAMP oscillation frequency in Dictyostelium reveals how signal modulation regulates gene expression and influences cellular decoding mechanisms.
RESEARCH ARTICLES
Spinal cord elongation enables proportional regulation of the zebrafish posterior body
Targeted ablation of dorsal progenitors in the zebrafish tailbud shows how the rate of spinal cord elongation governs the corresponding elongation of the neighbouring paraxial mesoderm.
Fate specification triggers a positive feedback loop of TEAD–YAP and NANOG to promote epiblast formation in preimplantation embryos
Summary: Epiblast fate specification by segregation of NANOG from GATA6 alters the transcriptional network and activates TEAD–YAP, triggering a positive feedback loop with NANOG to promote epiblast formation.
Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis
Summary: Under control of the transcription factor, Lmx1b, the hyaluronan-binding proteoglycan Versican and its chondroitin sulfate side chains regulate the density and hydration of hyaluronate-rich ECM to drive zebrafish semicircular canal morphogenesis.
CFI-1 functions unilaterally to restrict gap junction formation in C. elegans
Summary: Proper electrical coupling can be achieved by either partner cell, but each cell's influence on neural circuits may differ.
Her9 controls the stemness properties of hindbrain boundary cells
Summary: Zebrafish Her9 keeps boundary cells in the hindbrain as non-neurogenic progenitors by inhibiting Notch signaling and promotes their proliferation by controlling cell cycle regulators.
Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance
Summary: Stochastic modelling reveals that combining licensing with pairwise differentiation and niche competition is crucial for maintaining stem cell numbers and for preventing extinction in Drosophila testes.
TECHNIQUES AND RESOURCES
Establishment of CRISPR/Cas9-based knock-in in a hemimetabolous insect: targeted gene tagging in the cricket Gryllus bimaculatus
Summary: An efficient method allowing researchers to generate dominantly marked loss-of-function enhancer trap alleles of genes of interest in the cricket model species Gryllus bimaculatus.
Biologists @ 100 - join us in Liverpool in March 2025
We are excited to invite you to a unique scientific conference, celebrating the 100-year anniversary of The Company of Biologists, and bringing together our different communities. The conference will incorporate the Spring Meetings of the BSCB and the BSDB, the JEB Symposium Sensory Perception in a Changing World and a DMM programme on antimicrobial resistance. Find out more and register by 28 February 2025 to join us in March 2025 in Liverpool, UK.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
Development presents…
Development is excited to host a webinar series showcasing the latest developmental biology and stem cell research. The webinars are chaired each month by a different Development Editor, who invites talks from authors of exciting new papers and preprints. Visit Development presents... on the Node to see which topics are coming up and to catch up on recordings of past webinars.
Development’s Pathway to independence programme
We are delighted to announce a new call for our Pathway to Independence (PI) programme. This scheme is aimed at supporting postdocs planning to go on the job market in 2025, and will provide mentorship, training, networking and profile-raising opportunities. Apply by 31 Jan 2025.
Become a 2025 Node correspondent
The Node is looking for new correspondents to work together with the team to develop and produce content over the coming year. Apply by 20 January 2025.
