Issues

Summary: This Spotlight article delves into concepts and provides examples illustrating how single-cell transcriptomics unlocks the study of cell type evolution in diverse organisms.

Summary: This Review explores the diverse functional roles played by the oscillatory expression of bHLH family transcription factor Hes/Her genes and their targets during somitogenesis, neurogenesis, myogenesis and pancreas development.

Summary: Genetic ablation of Piezo1 and Piezo2 in neural crest cells impairs osteoblast differentiation and bone formation, whereas Piezo channel activation promotes mineralization in the developing jawbones.

Highlighted Article: During primary alveologenesis, alveolar myofibroblasts make up a proliferative mesenchymal lineage that is distinct from matrix fibroblasts and mature through several stages to populate emerging secondary septa.

Highlighted Article: Examination of intestinal organoids derived from a patient carrying functional variants of RFX6 reveals a loss of duodenal identity and identifies the molecular pathways that pattern the proximal small intestine.

Highlighted Article: Planarians grow and degrow whole-body shapes with different proportions, which is computationally explained by the dynamic feedback between morphogens and tissue growth and the differential apoptosis rate and pole signaling.

Summary: Although Prox1 is a key factor in lymphatic endothelial cell development, little is known about its cis-regulation. Here, we characterise multiple prox1a enhancers active in subsets of zebrafish lymphatic vasculature.

Highlighted Article: Inter-organ lipid distribution by scavenger receptor–lipoprotein interplay mediates adipocyte-to-ovary allocation of lipids.