Issues

Summary: This Development at a glance article gives an overview of mammalian spermatogenesis, a multi-step developmental process involving many cell types and regulated by intricate gene expression programs comprising signaling molecules, transcription factors and epigenetic modifiers.

Summary: Redundancy between Lgd and Alix, and coordination with the cell cycle kinase Cdk1, confers robust and timely abscission of Drosophila germline stem cells.

Highlighted Article: Tracking nutrient-sensing enteroendocrine cells cellular and mitochondrial Ca²⁺ activity in live zebrafish during development reveals that gut microbiota play crucial roles in promoting EEC maturation and mitochondrial function.

Summary: Comprehensive transcriptomic and chromatin accessibility studies of Smyd1 and Chd4 null embryonic mouse hearts reveal that SMYD1 and CHD4 repress a group of common genes and pathways in developing hearts.

Summary: Ablation of Yap/Taz in Acta2-expressing neonatal lung fibroblasts during postnatal alveologenesis blunts alveolar development with marked impairment of functional myofibroblasts.

Highlighted Article: Analysis of recent live-imaging data of ERK signaling in the mouse blastocyst suggests a new model for cell fate specification with a spatially uniform FGF signal that allows extending the Waddington landscape of a single cell to the entire inner cell mass.

Summary: HD-Zip II transcription factors redundantly regulate columella stem cell activity by counteracting auxin-mediated differentiation downstream of the FEZ/SMB proliferative module.

Summary: This study investigates how the intricate interplay between proliferation and patterning mechanisms enables the precise and reproducible sculpting of three-dimensional organs.

Summary: END-seq reveals that Rad50 is involved in germ cell meiosis during spermatogenesis, providing insight into RAD50 function in meiotic DSB formation and end resection in vivo.

Summary: Acto3D, an open-source software, facilitates cost-effective, high-resolution 3D imaging of fluorescently labelled tissues, offering streamlined visualisation, detailed control, and minimised computing resources, ideal for widespread adoption in biological research.