Issues
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Cover image
Cover Image
Cover: Scanning electron microscopy image depicting macrophages forming a crown-like structure (pseudocoloured in green) around histolyzing larval adipocytes in freshly eclosed Drosophila melanogaster. At this stage, macrophages recycle matter from adipocytes and convert it into nutrients used by maturing adult tissues. See Research article by KrejÄová et al. (dev.202492).
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RESEARCH HIGHLIGHTS
INTERVIEWS
SPOTLIGHT
Clinical translation of pluripotent stem cell-based therapies: successes and challenges
Summary: Great advancements have been made in recent years to bring pluripotent stem cell-based therapies to the clinic. This Spotlight highlights promising clinical results and discusses challenges associated with clinical translation.
REVIEW
The journey of a generation: advances and promises in the study of primordial germ cell migration
Summary: This Review covers the mechanisms of primordial germ cell migration in model organisms and systems, emphasizing the guidance factors and signaling pathways necessary for colonization of the gonad.
STEM CELLS AND REGENERATION
Cadherin-dependent adhesion is required for muscle stem cell niche anchorage and maintenance
Summary: Genetic ablation of cadherin-based adhesion in skeletal muscle stem cells triggers activation, niche exit, precocious differentiation and subsequent depletion of the stem cell pool.
A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche
Summary: Identification of a previously undescribed neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche through multi-layered transcriptomics and computational analyses.
RESEARCH REPORT
The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination
Summary: Actin filaments in a specific conformational state are formed during oocyte fate establishment in Drosophila, and they are recognised only by a subset of actin-binding proteins.
RESEARCH ARTICLES
Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues
Summary: Fibronectin matrix substrate couples apical growth of frontal bone and coronal suture patency in early embryonic development, leading to calvarial pathologies when disrupted.
CFAP58 is involved in the sperm head shaping and flagellogenesis of cattle and mice
Summary: Analysis of genetic variants of bovine CFAP58 and loss of Cfap58 in mice reveals that CFAP58 is required for correct development of manchette structure during spermatogenesis, thereby affecting male fertility.
Temporally distinct roles of Aurora A in polarization of the C. elegans zygote
Highlighted Article: The cell cycle kinase Aurora A has two distinct roles in regulating the timing of cell polarization: a late role required for symmetry breaking, and an earlier function that ensures a unique polarity axis.
Nutrient deprivation induces mouse embryonic diapause mediated by Gator1 and Tsc2
Highlighted Article: Mouse embryonic diapause is induced by either decreased concentration of several nutrients in the uterine fluid of mice suffering from pre-implantation maternal starvation in vivo or nutrient deprivation in vitro.
Foxp and Skor family proteins control differentiation of Purkinje cells from Ptf1a- and Neurog1-expressing progenitors in zebrafish
Summary: Analysis of zebrafish mutants and lineage tracing of ptf1a-expressing progenitors reveal that Foxp and Skor family transcriptional regulators control the differentiation of Purkinje cells from neural progenitors expressing the proneural genes ptf1a and neurog1.
Macrophages play a nutritive role in post-metamorphic maturation in Drosophila
Highlighted Article: Macrophages adopt a unique metabolic profile to convert engulfed cell mass into lipoproteins and storage peptides that metabolically supplement other tissues during post-metamorphic maturation in Drosophila.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
