Issues

Summary: Development reflects on the 40 years since the homeobox was discovered and announces a subject collection marking the occasion.

Highlighted Article: Using 2D human gastruloids, TBXT is shown to influence the timing of the epithelial-to-mesenchymal transition in a dose-dependent manner during early mesoderm development.

Summary: A new hydrogel substrate enables spatial control of surface stiffness at the micrometer level, enabling local differentiation of human pluripotent stem cells and facilitating complex pattern formation.

Summary: Dve activity is required for the proper opsin coupling of two neurons that is established through signaling pathways from adjacent neurons that are functionally different.

Summary: Examination of multiple conditional knockout mice provides in vivo evidence of instructional signals between the different compartments of the intervertebral disc during the postnatal growth of mouse spine.

Summary: Examination of mutant cells as well as multiple single and double knockout mice reveals a mechanism whereby the CPLANE protein Fuzzy controls actin polymerization and ciliogenesis via p190ARhoGAP.

Summary: UBE2S is shown to have an indispensable regulatory role in mouse oocyte meiosis and female fertility.

Highlighted Article: Photoreceptor and interommatidial pigment cell terminal differentiation is unexpectedly interdependent, connected by an intercellular feedback mechanism that coordinates and promotes morphogenetic change to ensure correct 3D retinal pattern.

Summary: A zebrafish raptor mutant reveals that neural crest cell survival and subsequent craniofacial development require properly tuned autophagy.

Summary: Suppressor of cytokine signaling 2 (SOCS2) mutant mice reveal that the loss of function of SOCS2 disrupts mammary gland development and function.