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Summary: This Review explores the functions of polyploidy during multicellular development, displaying common features of polyploid cell types and highlighting differences between developmentally programmed and induced polyploidy.

RESEARCH REPORT

Summary: Genetic reduction of elevated noggin expression in Grhl2−/− embryos leads to rescue of epithelial morphology and partially restores maxillary prominence size and neural tube closure.

RESEARCH ARTICLES

Summary: The chromatin-binding proteins ING4 and ING5 perform essential overlapping roles in cell fate decisions during mouse heart development and are required for the expression of key developmental control genes.

Summary: A dome-shaped microtubule structure is identified in medaka that is present prior to sex determination in primordial germ cells and is maintained in females, contributing to oocyte polarity.

Summary: Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression while negatively regulating expression of WNT signaling repressors and neural genes within the mesoderm.

Highlighted Article: A tailored synthetic growth factor that selectively activates the FZD5:LRP6 receptor complex patterns neural progenitor cells into midbrain fate and gives rise to functional dopaminergic neurons in vitro and in vivo.

Summary: Changes in transcriptional dynamics of even-skipped upon halving Krüppel dosage reveal how the combination of direct transcription factor (TF)-DNA and indirect TF-TF interactions shape proper patterning.

Summary: Mitochondrial fission protein Drp1 regulates epithelial follicle cell differentiation in Drosophila oogenesis. Increasing ROS and mitochondrial fragmentation suppresses the defects in epithelial polarity, and differentiation in Drp1-depleted follicle cells.

Summary: Genetic analysis reveals that the ETS transcription factors Pnt and Yan fine-tune the expression of matrix metalloproteinase 2 (MMP2) during late oogenesis and follicle rupture in Drosophila melanogaster.

Summary: EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells. EphB1 is also required to prevent cortical and striatal axons from extending along developing ventral telencephalic vasculature.

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