Issues
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Cover image
Cover Image
Cover: Scanning electron microscopy image of an embryonic day 10.5 mouse embryo lacking the transcription factor Grhl2, and also one allele of the soluble morphogen noggin (Grhl2−/−;Nog+/−). This image represents a partial rescue of the Grhl2−/− open neural tube phenotype, via reduction of the elevated expression of noggin in these embryos. See Research article by de Vries at al. (dev202420).
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RESEARCH HIGHLIGHT
PERSPECTIVES
INTERVIEWS
REVIEW
Functional consequences of somatic polyploidy in development
Summary: This Review explores the functions of polyploidy during multicellular development, displaying common features of polyploid cell types and highlighting differences between developmentally programmed and induced polyploidy.
RESEARCH REPORT
Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse
Summary: Genetic reduction of elevated noggin expression in Grhl2−/− embryos leads to rescue of epithelial morphology and partially restores maxillary prominence size and neural tube closure.
RESEARCH ARTICLES
ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development
Summary: The chromatin-binding proteins ING4 and ING5 perform essential overlapping roles in cell fate decisions during mouse heart development and are required for the expression of key developmental control genes.
Sexually dimorphic dynamics of the microtubule network in medaka (Oryzias latipes) germ cells
Summary: A dome-shaped microtubule structure is identified in medaka that is present prior to sex determination in primordial germ cells and is maintained in females, contributing to oocyte polarity.
Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm
Summary: Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression while negatively regulating expression of WNT signaling repressors and neural genes within the mesoderm.
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification
Highlighted Article: A tailored synthetic growth factor that selectively activates the FZD5:LRP6 receptor complex patterns neural progenitor cells into midbrain fate and gives rise to functional dopaminergic neurons in vitro and in vivo.
Multifaceted effects on even-skipped transcriptional dynamics upon Krüppel dosage changes
Summary: Changes in transcriptional dynamics of even-skipped upon halving Krüppel dosage reveal how the combination of direct transcription factor (TF)-DNA and indirect TF-TF interactions shape proper patterning.
Mitochondrial morphology dynamics and ROS regulate apical polarity and differentiation in Drosophila follicle cells
Summary: Mitochondrial fission protein Drp1 regulates epithelial follicle cell differentiation in Drosophila oogenesis. Increasing ROS and mitochondrial fragmentation suppresses the defects in epithelial polarity, and differentiation in Drp1-depleted follicle cells.
ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila
Summary: Genetic analysis reveals that the ETS transcription factors Pnt and Yan fine-tune the expression of matrix metalloproteinase 2 (MMP2) during late oogenesis and follicle rupture in Drosophila melanogaster.
EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells
Summary: EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells. EphB1 is also required to prevent cortical and striatal axons from extending along developing ventral telencephalic vasculature.
CORRECTIONS
Interviews with Biologists @ 100 conference speakers

Explore our interviews with keynote speakers from the Biologists @ 100 conference, hosted to celebrate our publisher’s 100th anniversary, where we discuss climate change and biodiversity with Hans-Otto Pörtner and Jane Francis, health and disease with Charles Swanton and emerging technologies with Manu Prakash and Jennifer Lippincott-Schwartz.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues

Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology

In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. Together with our preprint highlights service, preLights, these perspectives help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
How to build a community site for developmental biologists

Our community site, the Node, has been serving the developmental and stem cell biology community for 15 years. In this post, our Community Manager, Joyce Yu, shares how the Node was born and describes how to build a community site from scratch.