Issues
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Cover image
Cover Image
Cover: Collage of RNA expression in the tail of a whole-mount zebrafish embryo composed from the channels of a 10-plex, quantitative, high-resolution RNA fluorescence in situ hybridization experiment performed using spectral imaging with signal amplification based on the mechanism of hybridization chain reaction (HCR). See Research article by Schulte at al. (dev202307).
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RESEARCH HIGHLIGHTS
PERSPECTIVES
INTERVIEWS
REVIEW
Development and evolution of the primate neocortex from a progenitor cell perspective
Summary: This Review explores key features of neocortical neurogenesis in development and evolution in the primate lineage by focusing on the cell biology and molecular features of progenitor cells.
STEM CELLS AND REGENERATION
Extraocular muscle stem cells exhibit distinct cellular properties associated with non-muscle molecular signatures
Summary: A characterisation of the gene regulatory networks underlying functional heterogeneity, taking extraocular and limb muscle stem cells as archetypes for high- and low-performing stem cell populations.
Fluctuation of lysosomal protein degradation in neural stem cells of the postnatal mouse brain
Summary: Lysosomal proteolytic activity fluctuates in neural stem cells in the dentate gyrus of juvenile, adult, aged and diseased brains.
Hindbrain boundaries as niches of neural progenitor and stem cells regulated by the extracellular matrix proteoglycan chondroitin sulphate
Summary: Transcriptomic analysis of hindbrain boundaries reveals that they harbor cells with neural progenitor and/or stem cell properties that rely on the local extracellular matrix to maintain their undifferentiated state.
RESEARCH ARTICLES
Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring
Highlighted Article: Placental ACKR3 plays an essential role in compartmentalising CXCL12 activity on the maternal side of the placenta: blockade of ACKR3 leads to severe developmental abnormalities and disrupted haematopoiesis and immune response in offspring.
Robust axis elongation by Nodal-dependent restriction of BMP signaling
Summary: Nodal signaling renders embryonic axis elongation in zebrafish blastoderm explants and intact embryos robust by suppressing BMP activity to allow effective cell intercalations.
Developmental regulation of cellular metabolism is required for intestinal elongation and rotation
Highlighted Article: Late-stage exposure to atrazine disrupts cellular metabolism in the developing gut tube, leading to transcriptional, cellular and metabolic changes that perturb the proper elongation and rotation of the intestine.
A mutation in F-actin polymerization factor suppresses the distal arthrogryposis type 5 PIEZO2 pathogenic variant in Caenorhabditis elegans
Summary: A forward genetic suppressor screen in C. elegans identifies a potential suppressor on gex-3 , mitigating the reproductive defect induced by the DA5 mutation piezo-1(R2405P).
The MEK-ERK signaling pathway promotes maintenance of cardiac chamber identity
Summary: The MEK-ERK signaling pathway plays distinct roles in the maintenance of ventricular and atrial cardiomyocyte identities.
TECHNIQUES AND RESOURCES
HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples
Summary: Spectral imaging with signal amplification based on the mechanism of hybridization chain reaction enables robust 10-plex, quantitative, high-resolution imaging of RNA and protein targets in whole-mount vertebrate embryos and brain sections.
LiverZap: a chemoptogenetic tool for global and locally restricted hepatocyte ablation to study cellular behaviours in liver regeneration
Summary: LiverZap is a chemoptogenetic hepatocyte ablation tool that enables extended live imaging and targeted ablation of small hepatocyte populations. The latter condition unexpectedly activated progenitor-mediated regeneration, challenging the current understanding.
The Mediterranean mussel Mytilus galloprovincialis: a novel model for developmental studies in mollusks
Summary: A detailed developmental transcriptome for the bivalve mollusk Mytilus galloprovincialis and an expansion of the list of experimental protocols available for this species.
History of our journals
As our publisher, The Company of Biologists, turns 100 years old, read about Development’s journey and highlights from some its first issues, and explore the history of each of our sister journals: Journal of Cell Science, Journal of Experimental Biology, Disease Models & Mechanisms and Biology Open.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 15 May 2025.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
In preprints
Did you know that Development publishes perspectives on recent preprints? These articles help our readers navigate the ever-growing preprint literature. We welcome proposals for ‘In preprints’ articles, so please do get in touch if you’d like to contribute.
