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PRIMER

Summary: Epithelial-mesenchymal transition and its reverse mechanism, mesenchymal-epithelial transition, play crucial roles in regenerative medicine, contributing epigenetic changes in somatic cells to initiate reprogramming into stem cells and their subsequent differentiation into distinct lineages.

HUMAN DEVELOPMENT

Highlighted Article: Notch signalling is a crucial regulator of the induction and differentiation of posteriorly located neuromesodermal axial progenitors, the precursors of the neural and mesodermal components of the amniote embryonic body trunk.

STEM CELLS AND REGENERATION

Highlighted Article: Examination of the embryonic origins of mouse cranial sutures by genetic labelling reveals the contributions of neural crest, mesoderm and skeletal stem cells, focusing on repair of calvarial wounds.

RESEARCH REPORT

Summary: amg-1 mutation causes mitochondrial partitioning defects that trigger the mitochondrial unfolded protein response and phagocytic clearance and impair spermatogenesis in Caenorhabditis elegans.

RESEARCH ARTICLES

Highlighted Article: Comparison of two mouse strains reveals that cell division angle within the external granule cell layer of the cerebellum varies regionally and correlates with tissue mechanics that could set the amount and wavelength of folding.

Summary: A DAF-2(A261V) mutant corresponding to a human disease variant, clarifies the mechanism by which captopril and acn-1 control aging by regulating dauer formation and interacting with daf genes.

REVIEW COMMONS TRANSFER

Summary: Morphogen dynamics can have spatial dependence, e.g. in the diffusivity, that can impact gradient extent and the speed of formation.

Summary: FGF differentially regulates Rho and Rac activity at the lens equator to promote lens fiber cell elongation and migration in mouse.

Summary: 4D-lineage analysis and volumetric quantifications of the C lineage of Caenorhabditis elegans reveal that embryonic neuroblast size requires successive unequal cleavages that are regulated by key proneural transcription factors.

Summary: The development of microglia and brain-associated dendritic cells in the adult zebrafish brain is orchestrated by distinct genetic networks formed by the transcriptional regulators Zeb2a, Id2a and Batf3.

Summary: CRISPR/Cas9 knockout lines removing svp specifically from T2NB lineages show that Svp is required for the late born P-FN fate while restricting the early born P-EN fate.

Summary: This study generates a transcriptional roadmap of mouse gastrulation to organogenesis (E6.5-E9.5) and uses it to uncover complex waves of blood and endothelial development and interpret state-fate transplantation experiments.

TECHNIQUES AND RESOURCES

Summary: Comprehensive curation of Drosophila signaling pathways and new visual displays of the pathways provide a new FlyBase resource for researchers, and new insights into signaling pathway architecture.

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