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OBITUARY

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REVIEW

Summary: A survey of cellular selection processes across diverse physiological contexts suggests that a broader view of the cell competition concept would benefit understanding of cell–cell interactions in heterogeneous tissues.

STEM CELLS AND REGENERATION

Summary: Mouse Nr4a1/Nr4a2/ embryos lack hematopoietic stem cell activity at E11.5, implicating NR4A orphan nuclear receptors in endothelial-to-hematopoietic transition, a key step in in hematopoietic stem cell specification.

Highlighted Article: An inducible Cas3*/Cas7* sensor demonstrates that non-apoptotic caspase events occur in zebrafish neural stem cells. In cooperation with the stress-induced transcription factor Atf3, they often result in direct neuronal generation.

Summary: Single-cell RNA sequencing in the large yellow croaker provides insights into the development of spermatogonial stem cells, potentially impacting further conservation and culture of spermatogonial stem cells in teleosts.

Summary: Vegfc drives coronary lymphangiogenesis in zebrafish hearts, with distinct sources during development and regeneration, and Vegfc overexpression induces ectopic ventricular lymphatics, promoting scar resolution after heart injury.

Highlighted Article: Autonomous anteroposterior polarization in aggregates of mouse embryonic stem cells illustrates how alternative initial cell states between the embryo and the aggregates may converge onto similar fates.

Summary: The nuclear lamina protein Emerin plays a dual role in the survival of Drosophila germline stem cells by maintaining nuclear lamina structure and ensuring reduction of pericentriolar material.

RESEARCH REPORTS

Highlighted Article: Differentiation of mouse liver progenitors to functional hepatocytes requires anisotropic elongation of their nascent apical surfaces into tubular bile canaliculi.

REVIEW COMMONS TRANSFER

Summary: A membraneless organelle in the wasp Nasonia vitripennis is assembled from a Tudor protein shell and core germ granules, providing a new paradigm and resource for studying the remarkable plasticity of biomolecular condensates.

RESEARCH ARTICLES

Summary: Semaphorin 6A expressed by retinal ganglion cells directs laminar segregation of OFF and ON starburst amacrine cell dendritic scaffolds, playing an active role in specialization of ON versus OFF domains of the inner plexiform layer.

Summary: Peripheral nerve-derived CXCL12 signals through its receptor CXCR4 in lymphatic endothelial cells to regulate lymphatic sprouting and patterning.

Highlighted Article: The mitochondrial citrate carrier, SLC25A1, regulates trophoblast differentiation and placental development to safeguard embryonic heart formation.

Summary: Single-cell RNA sequencing reveals an age-related decline in zebrafish spermatogenesis. Aged testes show reduced sperm production, altered spermatogonial gene expression and expanded immune cell populations.

Summary: Evolutionary insights into sperm nuclear basic proteins (SNBPs) in Steatoda nobilis, using novel extraction methods and mass spectrometry to examine protamines and chromatin organization.

Summary: Mutation of hhip in zebrafish induces abundant radial bones of pectoral fins, analogous to those of basal fishes, suggesting the importance of Hedgehog signaling suppression by hhip in teleosts.

Summary: This study reveals an unexpected functional link between Ednrb signaling and the DNA sensor/tumor suppressor Aim2 in regulating neural crest-derived melanoblast proliferation.

Summary: Examination of Drosophila mutants in which basal membranes fail to form reveals a role for viscous forces in epithelial folding.

Summary: Mouse and human stem cell models of SMPD4 loss of function demonstrate that SMPD4 promotes cilia function and neural development.

TECHNIQUES AND RESOURCES

Summary: A new lizard embryonic fibroblast cell line is generated to enable in vitro studies of reptilian gene function.

Summary: A comprehensive collection of endogenously epitope- or fluorescent-tagged components of the Drosophila TGF-β/BMP signaling pathway can be used to assess localization and function of the corresponding proteins.

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