Issues
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Cover image
Cover Image
Cover: A ‘Swiss roll’ preparation of a 2-month-old aSmaCre: mTmG mouse large intestine. Dividing cells are highlighted in yellow (Ki67), cell membranes in turquoise (Tomato), and fibroblasts and muscle cells in blue (Cre-induced EGFP fluorescence in αSMA+ cells). See Research article by Simonin et al. (dev203038). Image courtesy of Neda Glisovic (Institut Curie, Paris, France).
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RESEARCH HIGHLIGHT
PERSPECTIVES
OBITUARY
INTERVIEWS
SPOTLIGHT
Almost 40 years of studying homeobox genes in C. elegans
Summary: This Spotlight looks at the history of the C. elegans homeobox field, discussing the prevalent role of homeodomain protein expression and function in C. elegans nervous system development.
REVIEW
Evolution and development of complex floral displays
Summary: There are over 300,000 species of flowering plants, with enormous variation in their floral display. This Review explores the development of this diversity, based on our understanding from model systems.
STEM CELLS AND REGENERATION
Allometry in limb regeneration and scale-invariant patterning as the basis of normal morphogenesis from different sizes of blastemas
Highlighted Article: Axolotl limb regeneration demonstrates scale-invariant patterning and allometric scaling, ensuring consistent limb morphogenesis from varying blastema sizes through coordinated Shh and Fgf8 signaling.
Ribosome biogenesis is essential for hemogenic endothelial cells to generate hematopoietic stem cells
Summary: The indispensable role of ribosome biogenesis in the generation of hematopoietic stem cells from hemogenic endothelial cells.
The GTPase RAB6 is required for stem cell maintenance and cell migration in the gut epithelium
Summary: Deletion of RAB6, a key regulator of intracellular transport in the mouse gut epithelium reveals that this protein is required for the maintenance of gut epithelial homeostasis.
RESEARCH ARTICLES
Planar cell polarity zebrafish models of congenital scoliosis reveal underlying defects in notochord morphogenesis
Summary: Analysis of ptk7a mutant zebrafish reveals a pathogenic mechanism for congenital scoliosis that is associated with defects in planar cell polarity-mediated convergence and extension of the notochord.
Target gene responses differ when transcription factor levels are acutely decreased by nuclear export versus degradation
Summary: Optogenetic tools can be used to determine how transcription factor levels and nuclear retention impact a dynamic patterning process.
Symmetry breaking and fate divergence during lateral inhibition in Drosophila
Summary: Real-time analysis of lateral inhibition reveals early symmetry breaking, rapid fate divergence promoted by heterogeneity in proneural factor accumulation and the role of cell-cell intercalation in pattern refinement.
Y box-binding protein 1 regulates zebrafish folliculogenesis partly through p21-mediated control of follicle cell proliferation
Summary: Y box-binding protein 1 controls early ovarian follicle development in zebrafish, and its loss results in a blockade of follicles at the transition from previtellogenic to vitellogenic growth.
Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea
Summary: Jag1-regulated Notch signaling controls cochlear patterning, affecting inner and outer hair cell specification, and hearing in Alagille syndrome, as shown by the Jag1Ndr/Ndr mouse model.
Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath
Summary: Axin1, a scaffold protein of canonical Wnt signaling, regulates tooth root development in mouse by inhibiting AKT1-mTORC1 activation and Shh translation in a Wnt-independent fashion.
Common modes of ERK induction resolve into context-specific signalling via emergent networks and cell-type-specific transcriptional repression
Summary: A newly developed tool allowing precise activation of ERK in the tissue and at the time of choice used to provide a framework for ERK context dependence, where activated transcriptional and chromatin responses show greater commonality than repressed ones.
C. elegans epicuticlins define specific compartments in the apical extracellular matrix and function in wound repair
Summary: Analysis of localization and function of epicuticlins, which are tandem repeat proteins associated with the lipid-rich epicuticle layer of the C. elegans cuticle.
TECHNIQUES AND RESOURCES
Nuclear instance segmentation and tracking for preimplantation mouse embryos
Summary: Image analysis pipeline for 3D nuclear instance segmentation and lineage tracking for preimplantation mouse embryos, including description of new H2B-miRFP720 reporter line and a large ground-truth dataset of nuclear instances.
Tracking and measuring local protein synthesis in vivo
Summary: This study describes a protein synthesis reporter that is near-instantaneous, in vivo, quantifiable and resettable.
The Company of Biologists Workshops
For the last 15 years, our publisher, The Company of Biologists, has provided an apt environment to inspire biology and support biologists through our Workshops series. Read about the evolution of the Workshop series and revisit JEB's experience with hosting the first Global South Workshop.
Call for papers – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
Development invites you to submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues. This issue will be coordinated by Guest Editors Meritxell Huch (Max Planck Institute of Molecular Cell Biology and Genetics, Germany) and Mansi Srivastava (Harvard University and Museum of Comparative Zoology, USA), working alongside our team of academic Editors. Submit your articles by 30 May 2025.
Meet our 2025 Pathway to Independence (PI) fellows
We are delighted to announce our third cohort of PI fellows - researchers whom we will be supporting as they transition from postdoc to Principal Investigator. Read about the eight talented fellows chosen, whom we're excited to be working with as they navigate the job market.
A case for broadening our view of mechanism in developmental biology
In this Perspective, B. Duygu Özpolat and colleagues survey researchers on their views on what it takes to infer mechanism in developmental biology. They examine what factors shape our idea of what we mean by ‘mechanism’ and suggest a path forward that embraces a broad outlook on the diversity of studies that advance knowledge in our field.
the Node: Have your say
Our community site, the Node, is conducting a user survey about the content and the design of the site. Help us shape the Node's future and thank you for being a part of the Node over the last 15 years.
